An outbreak of Phialemonium infective endocarditis linked to intracavernous penile injections for the treatment of impotence

Jacob Strahilevitz, Galia Rahav, Hans Josef Schroers, Richard C. Summerbell, Ziva Amitai, Anna Goldschmied-Reouven, Ethan Rubinstein, Yvonne Schwammenthal, Micha S. Feinberg, Yardena Siegman-Igra, Edna Bash, Itzhack Polacheck, Adrian Zelazny, Susan J. Howard, Pnina Cibotaro, Ora Shovman, Nathan Keller

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background. In March 2002, a patient in Tel Aviv, Israel, died of endocarditis caused by Phialemonium curvatum. As part of his therapy for erectile dysfunction, the patient had been trained to self-inject a compound of vasoactive drugs provided by an impotence clinic into his penile corpus cavernosous. Methods. We identified the used prefilled syringes as the source of his infection. Similar cases were investigated as a putative outbreak of P. curvatum invasive disease among customers of this impotence clinic. P. curvatum isolates, cultured from samples obtained from the patients and from prefilled syringes, were compared by DNA sequencing of the nuclear ribosomal internal transcribed spacer. Results. We identified 2 additional customers at the impotence clinic who had P. curvatum endocarditis. In addition, cultures of unused, prefilled syringes and bottles provided by the same clinic to 5 asymptomatic customers tested positive for pathogenic molds (P. curvatum in 4 cases and Paecilomyces lilacinus in 1). All P. curvatum isolates were of a single genetic type that is known only from this outbreak but is closely related to 3 other P. curvatum genotypes associated with pathogenicity in humans. Conclusions. P. curvatum is an emerging pathogen that can be readily isolated from blood. We identified an outbreak of P. curvatum endocarditis among men who had erectile dysfunction treated by intracavernous penile injections from contaminated prefilled syringes. © 2005 by the Infectious Diseases Society of America. All rights reserved.
    Original languageEnglish
    Pages (from-to)781-786
    Number of pages5
    JournalClinical Infectious Diseases
    Volume40
    Issue number6
    DOIs
    Publication statusPublished - 15 Mar 2005

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