Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

Claire L. Arthurs; Natasha S. Wind; Roger C. Whitehead; Ian J. Stratford

doi:10.1016/j.bmcl.2006.09.072

Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

Claire L. Arthurs, Natasha S. Wind, Roger C. Whitehead, Ian J. Stratford

Research output: Contribution to journal › Article › peer-review

Abstract

The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented. © 2006.

Original language	English
Pages (from-to)	553-557
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2006.09.072
Publication status	Published - 15 Jan 2007

Keywords

Anti-tumor
Glutathione transferase
Natural product
Organo-fluorine
Synthetic analogue

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2006.09.072

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title = "Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties",

abstract = "The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented. {\textcopyright} 2006.",

keywords = "Anti-tumor, Glutathione transferase, Natural product, Organo-fluorine, Synthetic analogue",

author = "Arthurs, {Claire L.} and Wind, {Natasha S.} and Whitehead, {Roger C.} and Stratford, {Ian J.}",

year = "2007",

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doi = "10.1016/j.bmcl.2006.09.072",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

AU - Arthurs, Claire L.

AU - Wind, Natasha S.

AU - Whitehead, Roger C.

AU - Stratford, Ian J.

PY - 2007/1/15

Y1 - 2007/1/15

N2 - The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented. © 2006.

AB - The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented. © 2006.

KW - Anti-tumor

KW - Glutathione transferase

KW - Natural product

KW - Organo-fluorine

KW - Synthetic analogue

U2 - 10.1016/j.bmcl.2006.09.072

DO - 10.1016/j.bmcl.2006.09.072

M3 - Article

SN - 1464-3405

VL - 17

SP - 553

EP - 557

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

Abstract

Keywords

UN SDGs

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