Analyses of cancer incidence and causes of death in child-parent trios: clues to aetiology of childhood central nervous system (CNS) tumours

Robert David Alston, Jillian Maud Birch, Anna Kelsey, Gareth Evans

    Research output: Contribution to conferencePoster

    Abstract

    Purpose: In most childhood CNS tumours aetiology is unknown. However a small proportion of cases occur with heritable syndromes. Familial cancer patterns may give pointers to environmental as well as genetic causes.Methods: CNS tumour cases from North West England, diagnosed under age 15 years, 1954–2008, and their parents were traced and flagged at the English National Health Service Information Centre. This provides continuous, prospective notification of incident cancers and causes of death. Expected numbers (E) of cancers within the cohort were calculated from national cancer incidence rates and compared with the observed (O) using Poisson regression.Results: The cohort included 1389 case children, 1178 mothers and 1078 fathers. There were 297 cancers in parents below the age of 80 years. (E = 266, P = 0.03) including 18 CNS tumours (E = 7.45, P = 0.001) and 3 bone sarcomas (E = 0.58, P = 0.02). 31 cancers occurred between ages 15 and 39 years (E = 17.2, P = 0.002) including 8 breast cancers (E = 3.7, P = 0.04). There were 44 subsequent primaries in case children (E = 9.3, P <0.0001) including 23 CNS tumours, some of which may be therapy related (E = 0.57, P <0.001) and 3 breast cancers under 40 years (E = 0.51, P = 0.02) which may be syndrome related. Analyses of clustering of cancers in parents with subsequent primaries and other factors in case children, together with causes of death in parents, will be conducted to explore putative genetic and environmental factors.Conclusion: Cancer excesses in case children and their parents may be syndrome-associated but might also relate to environmental agents relevant to aetiology of childhood CNS tumours.
    Original languageEnglish
    Publication statusPublished - Oct 2012
    Event44th Congress of the International Society for Paediatric Oncology (SIOP) - Carbican Centre, London
    Duration: 5 Oct 20128 Oct 2012

    Conference

    Conference44th Congress of the International Society for Paediatric Oncology (SIOP)
    CityCarbican Centre, London
    Period5/10/128/10/12

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