Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

Elizabeth Fullam; Areej Abuhammad; David L Wilson; Matthew C Anderton; Steve G Davies; Angela J Russell; Edith Sim

doi:10.1016/j.bmcl.2010.12.099

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

Elizabeth Fullam
, Areej Abuhammad
, David L Wilson
, Matthew C Anderton
, Steve G Davies
, Angela J Russell
, Edith Sim^*

^*Corresponding author for this work

Chemical Biology and Biological Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.

Original language	English
Pages (from-to)	1185-1190
Number of pages	6
Journal	Bioorganic & medicinal chemistry letters
Volume	21
Issue number	4
Early online date	24 Dec 2010
DOIs	https://doi.org/10.1016/j.bmcl.2010.12.099
Publication status	Published - 15 Feb 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

tuberculosis
Arylamine N-acetyltransferase
β-Amino alcohols
enzyme inhibition
drug discovery

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10.1016/j.bmcl.2010.12.099

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title = "Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase",

abstract = "The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.",

keywords = "tuberculosis, Arylamine N-acetyltransferase, β-Amino alcohols, enzyme inhibition, drug discovery",

author = "Elizabeth Fullam and Areej Abuhammad and Wilson, \{David L\} and Anderton, \{Matthew C\} and Davies, \{Steve G\} and Russell, \{Angela J\} and Edith Sim",

year = "2011",

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day = "15",

doi = "10.1016/j.bmcl.2010.12.099",

language = "English",

volume = "21",

pages = "1185--1190",

journal = "Bioorganic \& medicinal chemistry letters",

issn = "0960-894X",

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}

TY - JOUR

T1 - Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

AU - Fullam, Elizabeth

AU - Abuhammad, Areej

AU - Wilson, David L

AU - Anderton, Matthew C

AU - Davies, Steve G

AU - Russell, Angela J

AU - Sim, Edith

PY - 2011/2/15

Y1 - 2011/2/15

N2 - The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.

AB - The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.

KW - tuberculosis

KW - Arylamine N-acetyltransferase

KW - β-Amino alcohols

KW - enzyme inhibition

KW - drug discovery

U2 - 10.1016/j.bmcl.2010.12.099

DO - 10.1016/j.bmcl.2010.12.099

M3 - Article

C2 - 21251821

SN - 0960-894X

VL - 21

SP - 1185

EP - 1190

JO - Bioorganic & medicinal chemistry letters

JF - Bioorganic & medicinal chemistry letters

IS - 4

ER -

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

Abstract

UN SDGs

Keywords

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