Analysis of brain regional distribution of aluminium in rats via oral andintraperitoneal administration

Ramon Soto-Otero (Collaborator), Javier Iglesias-Gonzalez (Collaborator), Carmen Barciela-Alonso (Collaborator), Pilar Bermejo-Barrera (Collaborator), Estefania Mendez-Alvarez (Collaborator)

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In the present work, accumulation and distribution of aluminium in the rat brain following both intraperitoneal andoral administration were studied. Electrothermal atomic absorption spectrometry was used to determine aluminiumconcentration in different brain areas (cerebellum, ventral midbrain, cortex, hippocampus, and striatum). Most of thebrain areas showed accumulation of aluminium, but a greater and more significant increase was noted in the groupreceiving aluminium via intraperitoneal administration. Aluminium distribution was also dependent on theadministration route.
    Original languageEnglish
    Pages (from-to)31-34
    Number of pages3
    JournalJournal of Trace Elements in Medicine and Biology
    Volume21
    Issue numberS1
    DOIs
    Publication statusPublished - 10 Sept 2007

    Keywords

    • Aluminium
    • Brain distribution
    • Intraperitoneal
    • Oral
    • Rat

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