Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas

S. J. Calvert; C. J P Jones; C. P. Sibley; J. D. Aplin; A. E P Heazell

doi:10.1016/j.placenta.2013.10.001

Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas

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Abstract

Syncytial nuclear aggregates (SNAs) are increased in pregnancy complications and include 'true' syncytial knots and inter-villous bridges. Apparent nuclear overlay caused by sectioning artefacts are frequently counted from single sections. Haematoxylin and eosin stained serial sections were assessed for frequency of SNA subtypes in placentas from normal, preeclamptic and fetal growth restricted (FGR) pregnancies. There were more sectioning artefacts and syncytial knots and fewer bridges in samples from preeclampsia compared to controls. There were no significant differences between FGR and control samples. This suggests the villous tree in preeclampsia has less inherent structural support and trophoblast cell dynamics are different. © 2013 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1251-1254
Number of pages	3
Journal	Placenta
Volume	34
Issue number	12
DOIs	https://doi.org/10.1016/j.placenta.2013.10.001
Publication status	Published - Dec 2013

Keywords

Fetal growth restriction
Preeclampsia
Sectioning artefact
Syncytial bridge
Syncytial knot
Syncytiotrophoblast

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10.1016/j.placenta.2013.10.001

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title = "Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas",

abstract = "Syncytial nuclear aggregates (SNAs) are increased in pregnancy complications and include 'true' syncytial knots and inter-villous bridges. Apparent nuclear overlay caused by sectioning artefacts are frequently counted from single sections. Haematoxylin and eosin stained serial sections were assessed for frequency of SNA subtypes in placentas from normal, preeclamptic and fetal growth restricted (FGR) pregnancies. There were more sectioning artefacts and syncytial knots and fewer bridges in samples from preeclampsia compared to controls. There were no significant differences between FGR and control samples. This suggests the villous tree in preeclampsia has less inherent structural support and trophoblast cell dynamics are different. {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",

keywords = "Fetal growth restriction, Preeclampsia, Sectioning artefact, Syncytial bridge, Syncytial knot, Syncytiotrophoblast",

author = "Calvert, \{S. J.\} and Jones, \{C. J P\} and Sibley, \{C. P.\} and Aplin, \{J. D.\} and Heazell, \{A. E P\}",

year = "2013",

month = dec,

doi = "10.1016/j.placenta.2013.10.001",

language = "English",

volume = "34",

pages = "1251--1254",

journal = "Placenta",

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TY - JOUR

T1 - Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas

AU - Calvert, S. J.

AU - Jones, C. J P

AU - Sibley, C. P.

AU - Aplin, J. D.

AU - Heazell, A. E P

PY - 2013/12

Y1 - 2013/12

N2 - Syncytial nuclear aggregates (SNAs) are increased in pregnancy complications and include 'true' syncytial knots and inter-villous bridges. Apparent nuclear overlay caused by sectioning artefacts are frequently counted from single sections. Haematoxylin and eosin stained serial sections were assessed for frequency of SNA subtypes in placentas from normal, preeclamptic and fetal growth restricted (FGR) pregnancies. There were more sectioning artefacts and syncytial knots and fewer bridges in samples from preeclampsia compared to controls. There were no significant differences between FGR and control samples. This suggests the villous tree in preeclampsia has less inherent structural support and trophoblast cell dynamics are different. © 2013 Elsevier Ltd. All rights reserved.

AB - Syncytial nuclear aggregates (SNAs) are increased in pregnancy complications and include 'true' syncytial knots and inter-villous bridges. Apparent nuclear overlay caused by sectioning artefacts are frequently counted from single sections. Haematoxylin and eosin stained serial sections were assessed for frequency of SNA subtypes in placentas from normal, preeclamptic and fetal growth restricted (FGR) pregnancies. There were more sectioning artefacts and syncytial knots and fewer bridges in samples from preeclampsia compared to controls. There were no significant differences between FGR and control samples. This suggests the villous tree in preeclampsia has less inherent structural support and trophoblast cell dynamics are different. © 2013 Elsevier Ltd. All rights reserved.

KW - Fetal growth restriction

KW - Preeclampsia

KW - Sectioning artefact

KW - Syncytial bridge

KW - Syncytial knot

KW - Syncytiotrophoblast

U2 - 10.1016/j.placenta.2013.10.001

DO - 10.1016/j.placenta.2013.10.001

M3 - Article

C2 - 24172869

SN - 0143-4004

VL - 34

SP - 1251

EP - 1254

JO - Placenta

JF - Placenta

IS - 12

ER -

Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas

Abstract

Keywords

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