Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report

B.J. Canning; Anne B. Chang; Donald C Bolser; Jaclyn A Smith; Stuart Mazzone; Lorcan McGarvey; TM Adams; KW Altman; AF Barker; SS Birring; Fiona Blackhall; DC Bolser; LP Boulet; SS Braman; C Brightling; P Callahan-Lyon; B Canning; AB Chang; R Coeytaux; T Cowley; P Davenport; RL Diekemper; S Ebihara; AA El Solh; P Escalante; A Feinstein; SK Field; D Fisher; CT French; P Gibson; P Gold; C Grant; SM Harding; A Harnden; AT Hill; RS Irwin; PJ Kahrilas; KA Keogh; AP Lane; SZ Lewis; K Lim; MA Malesker; P Mazzone; S Mazzone; L McGarvey; A Molasiotis; MH Murad; P Newcombe; HQ Nguyen; J Oppenheimer; D Prezant; T Pringsheim; MI Restrepo; M Rosen; M Rubin; JH Ryu; Smith J; SM Tarlo; RB Turner; A Vertigan; G Wang; K Weir

doi:10.1378/chest.14-1481

Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report

B.J. Canning, Anne B. Chang, Donald C Bolser, Jaclyn A Smith, Stuart Mazzone, Lorcan McGarvey, TM Adams, KW Altman, AF Barker, SS Birring, Fiona Blackhall, DC Bolser, LP Boulet, SS Braman, C Brightling, P Callahan-Lyon, B Canning, AB Chang, R Coeytaux, T CowleyP Davenport, RL Diekemper, S Ebihara, AA El Solh, P Escalante, A Feinstein, SK Field, D Fisher, CT French, P Gibson, P Gold, C Grant, SM Harding, A Harnden, AT Hill, RS Irwin, PJ Kahrilas, KA Keogh, AP Lane, SZ Lewis, K Lim, MA Malesker, P Mazzone, S Mazzone, L McGarvey, A Molasiotis, MH Murad, P Newcombe, HQ Nguyen, J Oppenheimer, D Prezant, T Pringsheim, MI Restrepo, M Rosen, M Rubin, JH Ryu, Smith J, SM Tarlo, RB Turner, A Vertigan, G Wang, K Weir

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.

Original language	English
Journal	Chest
DOIs	https://doi.org/10.1378/chest.14-1481
Publication status	Published - 4 Sept 2014

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Manchester Cancer Research Centre

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Canning, B. J., Chang, A. B., Bolser, D. C., Smith, J. A., Mazzone, S., McGarvey, L., Adams, TM., Altman, KW., Barker, AF., Birring, SS., Blackhall, F., Bolser, DC., Boulet, LP., Braman, SS., Brightling, C., Callahan-Lyon, P., Canning, B., Chang, AB., Coeytaux, R., ... Weir, K. (2014). Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report. Chest. https://doi.org/10.1378/chest.14-1481

@article{2c81e42752d148c098f64faf0b8554ac,

title = "Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report",

abstract = "Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.",

author = "B.J. Canning and Chang, {Anne B.} and Bolser, {Donald C} and Smith, {Jaclyn A} and Stuart Mazzone and Lorcan McGarvey and TM Adams and KW Altman and AF Barker and SS Birring and Fiona Blackhall and DC Bolser and LP Boulet and SS Braman and C Brightling and P Callahan-Lyon and B Canning and AB Chang and R Coeytaux and T Cowley and P Davenport and RL Diekemper and S Ebihara and {El Solh}, AA and P Escalante and A Feinstein and SK Field and D Fisher and CT French and P Gibson and P Gold and C Grant and SM Harding and A Harnden and AT Hill and RS Irwin and PJ Kahrilas and KA Keogh and AP Lane and SZ Lewis and K Lim and MA Malesker and P Mazzone and S Mazzone and L McGarvey and A Molasiotis and MH Murad and P Newcombe and HQ Nguyen and J Oppenheimer and D Prezant and T Pringsheim and MI Restrepo and M Rosen and M Rubin and JH Ryu and Smith J and SM Tarlo and RB Turner and A Vertigan and G Wang and K Weir",

year = "2014",

month = sep,

day = "4",

doi = "10.1378/chest.14-1481",

language = "English",

journal = "Chest",

issn = "1931-3543",

publisher = "Elsevier BV",

}

Canning, BJ, Chang, AB, Bolser, DC, Smith, JA, Mazzone, S, McGarvey, L, Adams, TM, Altman, KW, Barker, AF, Birring, SS, Blackhall, F, Bolser, DC, Boulet, LP, Braman, SS, Brightling, C, Callahan-Lyon, P, Canning, B, Chang, AB, Coeytaux, R, Cowley, T, Davenport, P, Diekemper, RL, Ebihara, S, El Solh, AA, Escalante, P, Feinstein, A, Field, SK, Fisher, D, French, CT, Gibson, P, Gold, P, Grant, C, Harding, SM, Harnden, A, Hill, AT, Irwin, RS, Kahrilas, PJ, Keogh, KA, Lane, AP, Lewis, SZ, Lim, K, Malesker, MA, Mazzone, P, Mazzone, S, McGarvey, L, Molasiotis, A, Murad, MH, Newcombe, P, Nguyen, HQ, Oppenheimer, J, Prezant, D, Pringsheim, T, Restrepo, MI, Rosen, M, Rubin, M, Ryu, JH, J, S, Tarlo, SM, Turner, RB, Vertigan, A, Wang, G & Weir, K 2014, 'Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report', Chest. https://doi.org/10.1378/chest.14-1481

TY - JOUR

T1 - Anatomy and neurophysiology of cough

T2 - CHEST Guideline and Expert Panel report

AU - Canning, B.J.

AU - Chang, Anne B.

AU - Bolser, Donald C

AU - Smith, Jaclyn A

AU - Mazzone, Stuart

AU - McGarvey, Lorcan

AU - Adams, TM

AU - Altman, KW

AU - Barker, AF

AU - Birring, SS

AU - Blackhall, Fiona

AU - Bolser, DC

AU - Boulet, LP

AU - Braman, SS

AU - Brightling, C

AU - Callahan-Lyon, P

AU - Canning, B

AU - Chang, AB

AU - Coeytaux, R

AU - Cowley, T

AU - Davenport, P

AU - Diekemper, RL

AU - Ebihara, S

AU - El Solh, AA

AU - Escalante, P

AU - Feinstein, A

AU - Field, SK

AU - Fisher, D

AU - French, CT

AU - Gibson, P

AU - Gold, P

AU - Grant, C

AU - Harding, SM

AU - Harnden, A

AU - Hill, AT

AU - Irwin, RS

AU - Kahrilas, PJ

AU - Keogh, KA

AU - Lane, AP

AU - Lewis, SZ

AU - Lim, K

AU - Malesker, MA

AU - Mazzone, P

AU - Mazzone, S

AU - McGarvey, L

AU - Molasiotis, A

AU - Murad, MH

AU - Newcombe, P

AU - Nguyen, HQ

AU - Oppenheimer, J

AU - Prezant, D

AU - Pringsheim, T

AU - Restrepo, MI

AU - Rosen, M

AU - Rubin, M

AU - Ryu, JH

AU - J, Smith

AU - Tarlo, SM

AU - Turner, RB

AU - Vertigan, A

AU - Wang, G

AU - Weir, K

PY - 2014/9/4

Y1 - 2014/9/4

N2 - Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.

AB - Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves that regulate coughing are described. The brainstem and higher brain control systems that process this sensory information are complex, but our current understanding of them is considerable and increasing. The relevance of these neural systems to clinical phenomena, such as urge to cough and psychologic methods for treatment of dystussia, is high, and modern imaging methods have revealed potential neural substrates for some features of cough in the human.

U2 - 10.1378/chest.14-1481

DO - 10.1378/chest.14-1481

M3 - Article

SN - 1931-3543

JO - Chest

JF - Chest

ER -

Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report

Abstract

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