Aneuploidy is associated with azole resistance in Aspergillus fumigatus

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Azole resistance in Aspergillus fumigatus is on the rise. Non-target mediated mechanisms are a common cause of azole resistance in chronic pulmonary aspergillosis (CPA). Here we investigate resistance mechanisms using whole genome sequencing. Sixteen azole-resistant A. fumigatus isolates from CPA were sequenced to assess genome rearrangements. 7/16 CPA isolates showed genomic duplications compared to 0/18 invasive isolates. Duplication of regions including cyp51A increased gene expression. Our results suggest aneuploidy as an azole resistance mechanism in CPA.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Publication statusAccepted/In press - 9 Feb 2023


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