Aneurysmal SAH: Cognitive outcome and structural damage after clipping or coiling

Marios Hadjivassiliou, C. L. Tooth, C. A J Romanowski, J. Byrne, R. D E Battersby, S. Oxbury, C. S. Crewswell, E. Burkitt, N. A. Stokes, C. Paul, A. R. Mayes, H. J. Sagar

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Aneurysmal subarachnoid hemorrhage (SAH) and surgical clipping of intracranial aneurysms are associated with substantial morbidity and mortality. Objective: To compare cognitive outcome and structural damage in patients with aneurysmal SAH treated with surgical clipping or endovascular coiling. Methods: Forty case-matched pairs of patients with aneurysmal SAH treated by surgical clipping or endovascular coiling were prospectively assessed by use of a battery of cognitive tests. Twenty-three case-matched pairs underwent MRI 1 year after the procedure. Matching was based on grade of SAH on admission, location of aneurysm, age, and premorbid IQ. Results: Both groups were impaired in all cognitive domains when compared with age-matched healthy control subjects. Comparison of cognitive outcome between the two groups indicated an overall trend toward a poorer cognitive outcome in the surgical group, which achieved significance in four tests. MRI showed focal encephalomalacia exclusively in the surgical group. This group also had a significantly higher incidence of single or multiple small infarcts within the vascular territory of the aneurysm, but both groups had similar incidence of large infarcts and global ischemic damage. Conclusion: Endovascular treatment may cause less structural brain damage than surgery and have a more favorable cognitive outcome. However, cognitive outcome appears to be dictated primarily by the complications of SAH.
    Original languageEnglish
    Pages (from-to)1672-1677
    Number of pages5
    JournalNeurology
    Volume56
    Issue number12
    DOIs
    Publication statusPublished - 26 Jun 2001

    Fingerprint

    Dive into the research topics of 'Aneurysmal SAH: Cognitive outcome and structural damage after clipping or coiling'. Together they form a unique fingerprint.

    Cite this