Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer

G. J. Byrne; K. E. Hayden; G. McDowell; H. Lang; C. C. Kirwan; L. Tetlow; S. Kumar; N. J. Bundred

Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer

G. J. Byrne, K. E. Hayden, G. McDowell, H. Lang, C. C. Kirwan, L. Tetlow, S. Kumar, N. J. Bundred

Research output: Contribution to journal › Article › peer-review

Abstract

In cancer models, thrombospondin-1 (TSP-1) has been shown to inhibit angiogenesis or promote metastasis by increasing adhesion of malignant cells to endothelium. To determine the role of TSP-1 in breast cancer and breast cancer angiogenesis, we have measured TSP-1 in plasma and tumour cytosols and compared levels to established clinicopathological prognostic parameters and intratumoural microvessel density. TSP-1 was measured, by radioimmunoassay, in plasma (pTSP-1) and tumour cytosols (cTSP-1) of women with early breast cancer (EBC) (n=71). pTSP-1 in EBC was compared to pTSP-1 levels in women with advanced breast cancer (ABC) (n=66), normal controls (n=77) and was correlated with prognostic features and microvessel density (MVD) (measured by CD31 immunostaining). cTSP-1 levels were compared to prognostic features and microvessel density. pTSP-1 in women with EBC (median 484, IQR 344-877 ng/ml) and ABC (median 588, IQR 430-952 ng/ml) were elevated when compared to normal controls (median 21, IQR 175-247) (p

Original language	English
Pages (from-to)	1127-1132
Number of pages	5
Journal	International Journal of Oncology
Volume	31
Issue number	5
Publication status	Published - Nov 2007

Keywords

Angiogenesis
Breast cancer
Tumour marker

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Byrne, G. J., Hayden, K. E., McDowell, G., Lang, H., Kirwan, C. C., Tetlow, L., Kumar, S., & Bundred, N. J. (2007). Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer. International Journal of Oncology, 31(5), 1127-1132. http://www.spandidos-publications.com/serveFile/ijo_31_5_1127_PDF.pdf?type=article&article_id=ijo_31_5_1127&item=PDF

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title = "Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer",

abstract = "In cancer models, thrombospondin-1 (TSP-1) has been shown to inhibit angiogenesis or promote metastasis by increasing adhesion of malignant cells to endothelium. To determine the role of TSP-1 in breast cancer and breast cancer angiogenesis, we have measured TSP-1 in plasma and tumour cytosols and compared levels to established clinicopathological prognostic parameters and intratumoural microvessel density. TSP-1 was measured, by radioimmunoassay, in plasma (pTSP-1) and tumour cytosols (cTSP-1) of women with early breast cancer (EBC) (n=71). pTSP-1 in EBC was compared to pTSP-1 levels in women with advanced breast cancer (ABC) (n=66), normal controls (n=77) and was correlated with prognostic features and microvessel density (MVD) (measured by CD31 immunostaining). cTSP-1 levels were compared to prognostic features and microvessel density. pTSP-1 in women with EBC (median 484, IQR 344-877 ng/ml) and ABC (median 588, IQR 430-952 ng/ml) were elevated when compared to normal controls (median 21, IQR 175-247) (p",

keywords = "Angiogenesis, Breast cancer, Tumour marker",

author = "Byrne, {G. J.} and Hayden, {K. E.} and G. McDowell and H. Lang and Kirwan, {C. C.} and L. Tetlow and S. Kumar and Bundred, {N. J.}",

year = "2007",

month = nov,

language = "English",

volume = "31",

pages = "1127--1132",

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Byrne, GJ, Hayden, KE, McDowell, G, Lang, H, Kirwan, CC, Tetlow, L, Kumar, S & Bundred, NJ 2007, 'Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer', International Journal of Oncology, vol. 31, no. 5, pp. 1127-1132. <http://www.spandidos-publications.com/serveFile/ijo_31_5_1127_PDF.pdf?type=article&article_id=ijo_31_5_1127&item=PDF>

TY - JOUR

T1 - Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer

AU - Byrne, G. J.

AU - Hayden, K. E.

AU - McDowell, G.

AU - Lang, H.

AU - Kirwan, C. C.

AU - Tetlow, L.

AU - Kumar, S.

AU - Bundred, N. J.

PY - 2007/11

Y1 - 2007/11

N2 - In cancer models, thrombospondin-1 (TSP-1) has been shown to inhibit angiogenesis or promote metastasis by increasing adhesion of malignant cells to endothelium. To determine the role of TSP-1 in breast cancer and breast cancer angiogenesis, we have measured TSP-1 in plasma and tumour cytosols and compared levels to established clinicopathological prognostic parameters and intratumoural microvessel density. TSP-1 was measured, by radioimmunoassay, in plasma (pTSP-1) and tumour cytosols (cTSP-1) of women with early breast cancer (EBC) (n=71). pTSP-1 in EBC was compared to pTSP-1 levels in women with advanced breast cancer (ABC) (n=66), normal controls (n=77) and was correlated with prognostic features and microvessel density (MVD) (measured by CD31 immunostaining). cTSP-1 levels were compared to prognostic features and microvessel density. pTSP-1 in women with EBC (median 484, IQR 344-877 ng/ml) and ABC (median 588, IQR 430-952 ng/ml) were elevated when compared to normal controls (median 21, IQR 175-247) (p

AB - In cancer models, thrombospondin-1 (TSP-1) has been shown to inhibit angiogenesis or promote metastasis by increasing adhesion of malignant cells to endothelium. To determine the role of TSP-1 in breast cancer and breast cancer angiogenesis, we have measured TSP-1 in plasma and tumour cytosols and compared levels to established clinicopathological prognostic parameters and intratumoural microvessel density. TSP-1 was measured, by radioimmunoassay, in plasma (pTSP-1) and tumour cytosols (cTSP-1) of women with early breast cancer (EBC) (n=71). pTSP-1 in EBC was compared to pTSP-1 levels in women with advanced breast cancer (ABC) (n=66), normal controls (n=77) and was correlated with prognostic features and microvessel density (MVD) (measured by CD31 immunostaining). cTSP-1 levels were compared to prognostic features and microvessel density. pTSP-1 in women with EBC (median 484, IQR 344-877 ng/ml) and ABC (median 588, IQR 430-952 ng/ml) were elevated when compared to normal controls (median 21, IQR 175-247) (p

KW - Angiogenesis

KW - Breast cancer

KW - Tumour marker

M3 - Article

SN - 1019-6439

VL - 31

SP - 1127

EP - 1132

JO - International Journal of Oncology

JF - International Journal of Oncology

IS - 5

ER -

Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer

Abstract

Keywords

UN SDGs

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