Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells

Agapios Sachinidis; Peter Weisser; Yon Ko; Kerstin Schulte; Katharina Meyer zu Brickwedde; Ludwig Neyses; Hans Vetter

Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells

Agapios Sachinidis, Peter Weisser, Yon Ko, Kerstin Schulte, Katharina Meyer zu Brickwedde, Ludwig Neyses, Hans Vetter

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene. © 1992.

Original language	English
Pages (from-to)	109-112
Number of pages	3
Journal	FEBS Letters
Volume	313
Issue number	2
Publication status	Published - 23 Nov 1992

Keywords

Angiotensin II
Early growth responce gene-1 (Egr-1)
Vascular smooth muscle cell

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title = "Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells",

abstract = "The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene. {\textcopyright} 1992.",

keywords = "Angiotensin II, Early growth responce gene-1 (Egr-1), Vascular smooth muscle cell",

author = "Agapios Sachinidis and Peter Weisser and Yon Ko and Kerstin Schulte and {zu Brickwedde}, {Katharina Meyer} and Ludwig Neyses and Hans Vetter",

year = "1992",

month = nov,

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language = "English",

volume = "313",

pages = "109--112",

journal = "FEBS Letters",

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T1 - Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells

AU - Sachinidis, Agapios

AU - Weisser, Peter

AU - Ko, Yon

AU - Schulte, Kerstin

AU - zu Brickwedde, Katharina Meyer

AU - Neyses, Ludwig

AU - Vetter, Hans

PY - 1992/11/23

Y1 - 1992/11/23

N2 - The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene. © 1992.

AB - The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositolphosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene. © 1992.

KW - Angiotensin II

KW - Early growth responce gene-1 (Egr-1)

KW - Vascular smooth muscle cell

M3 - Article

VL - 313

SP - 109

EP - 112

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells

Abstract

Keywords

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