TY - JOUR
T1 - Angiotensin II signaling in human preadipose cells: participation of ERK1,2-dependent modulation of Akt.
AU - Dünner, N
AU - Quezada Bustos, Carolina
AU - Berndt, FA
AU - Cánovas, J
AU - Rojas, CV.
N1 - This study was supported by CONICYT, FONDECYT/Regular 1100126. http://www.conicyt.cl/fondecyt/.
PY - 2013/10/2
Y1 - 2013/10/2
N2 - The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation, glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic consequences of obesity. As we investigated angiotensin II signal transduction mechanisms in human preadipose cells, an interplay of extracellular-signal-regulated kinases 1 and 2 (ERK1,2) and Akt/PKB became evident. Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5±0.2-fold the control value without angiotensin II (p
AB - The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation, glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic consequences of obesity. As we investigated angiotensin II signal transduction mechanisms in human preadipose cells, an interplay of extracellular-signal-regulated kinases 1 and 2 (ERK1,2) and Akt/PKB became evident. Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5±0.2-fold the control value without angiotensin II (p
U2 - 10.1371/journal.pone.0075440
DO - 10.1371/journal.pone.0075440
M3 - Article
SN - 1932-6203
JO - P L o S One
JF - P L o S One
ER -
