Angiotensin II signaling in human preadipose cells: participation of ERK1,2-dependent modulation of Akt.

N Dünner; Carolina Quezada Bustos; FA Berndt; J Cánovas; CV. Rojas

doi:10.1371/journal.pone.0075440

Angiotensin II signaling in human preadipose cells: participation of ERK1,2-dependent modulation of Akt.

N Dünner
, Carolina Quezada Bustos
, FA Berndt
, J Cánovas
, CV. Rojas

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation, glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic consequences of obesity. As we investigated angiotensin II signal transduction mechanisms in human preadipose cells, an interplay of extracellular-signal-regulated kinases 1 and 2 (ERK1,2) and Akt/PKB became evident. Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5±0.2-fold the control value without angiotensin II (p

Original language	English
Journal	P L o S One
DOIs	https://doi.org/10.1371/journal.pone.0075440
Publication status	Published - 2 Oct 2013

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title = "Angiotensin II signaling in human preadipose cells: participation of ERK1,2-dependent modulation of Akt.",

abstract = "The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation, glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic consequences of obesity. As we investigated angiotensin II signal transduction mechanisms in human preadipose cells, an interplay of extracellular-signal-regulated kinases 1 and 2 (ERK1,2) and Akt/PKB became evident. Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5±0.2-fold the control value without angiotensin II (p",

author = "N D{\"u}nner and \{Quezada Bustos\}, Carolina and FA Berndt and J C{\'a}novas and CV. Rojas",

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AU - Dünner, N

AU - Quezada Bustos, Carolina

AU - Berndt, FA

AU - Cánovas, J

AU - Rojas, CV.

N1 - This study was supported by CONICYT, FONDECYT/Regular 1100126. http://www.conicyt.cl/fondecyt/.

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N2 - The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation, glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic consequences of obesity. As we investigated angiotensin II signal transduction mechanisms in human preadipose cells, an interplay of extracellular-signal-regulated kinases 1 and 2 (ERK1,2) and Akt/PKB became evident. Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5±0.2-fold the control value without angiotensin II (p

AB - The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation, glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic consequences of obesity. As we investigated angiotensin II signal transduction mechanisms in human preadipose cells, an interplay of extracellular-signal-regulated kinases 1 and 2 (ERK1,2) and Akt/PKB became evident. Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5±0.2-fold the control value without angiotensin II (p

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JO - P L o S One

JF - P L o S One

ER -

Angiotensin II signaling in human preadipose cells: participation of ERK1,2-dependent modulation of Akt.

Abstract

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