Angiotensinogen gene variants and small-for-gestational-age infants

C. Tower; S. Chappell; N. Kalsheker; P. Baker; L. Morgan

doi:10.1111/j.1471-0528.2005.00841.x

Angiotensinogen gene variants and small-for-gestational-age infants

C. Tower, S. Chappell, N. Kalsheker, P. Baker, L. Morgan

Research output: Contribution to journal › Article › peer-review

Abstract

In 2003, the angiotensinogen (AGT) gene was found to be associated with infants small for gestational age (SGA). The present study of 107 pregnancies affected by SGA infants and 101 normal pregnancies was designed to further investigate this association. Maternal or fetal AGT genotype or haplotype frequencies did not differ between SGA and normal pregnancies (P > 0.35). Quantitative trait analysis of mothers with normal pregnancies demonstrated an association between AGT haplotype and blood pressure and body mass index at antenatal booking (P= 0.04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women. © RCOG 2006 BJOG An International Journal of Obstetrics and Gynaecology.

Original language	English
Pages (from-to)	335-339
Number of pages	4
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	113
Issue number	3
DOIs	https://doi.org/10.1111/j.1471-0528.2005.00841.x
Publication status	Published - Mar 2006

Access to Document

10.1111/j.1471-0528.2005.00841.x

Cite this

@article{e9a7e236ab524e239667e59c5fb3cdcc,

title = "Angiotensinogen gene variants and small-for-gestational-age infants",

abstract = "In 2003, the angiotensinogen (AGT) gene was found to be associated with infants small for gestational age (SGA). The present study of 107 pregnancies affected by SGA infants and 101 normal pregnancies was designed to further investigate this association. Maternal or fetal AGT genotype or haplotype frequencies did not differ between SGA and normal pregnancies (P > 0.35). Quantitative trait analysis of mothers with normal pregnancies demonstrated an association between AGT haplotype and blood pressure and body mass index at antenatal booking (P= 0.04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women. {\textcopyright} RCOG 2006 BJOG An International Journal of Obstetrics and Gynaecology.",

author = "C. Tower and S. Chappell and N. Kalsheker and P. Baker and L. Morgan",

year = "2006",

month = mar,

doi = "10.1111/j.1471-0528.2005.00841.x",

language = "English",

volume = "113",

pages = "335--339",

journal = "BJOG: An International Journal of Obstetrics and Gynaecology",

issn = "1471-0528",

publisher = "John Wiley & Sons Ltd",

number = "3",

}

TY - JOUR

T1 - Angiotensinogen gene variants and small-for-gestational-age infants

AU - Tower, C.

AU - Chappell, S.

AU - Kalsheker, N.

AU - Baker, P.

AU - Morgan, L.

PY - 2006/3

Y1 - 2006/3

N2 - In 2003, the angiotensinogen (AGT) gene was found to be associated with infants small for gestational age (SGA). The present study of 107 pregnancies affected by SGA infants and 101 normal pregnancies was designed to further investigate this association. Maternal or fetal AGT genotype or haplotype frequencies did not differ between SGA and normal pregnancies (P > 0.35). Quantitative trait analysis of mothers with normal pregnancies demonstrated an association between AGT haplotype and blood pressure and body mass index at antenatal booking (P= 0.04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women. © RCOG 2006 BJOG An International Journal of Obstetrics and Gynaecology.

AB - In 2003, the angiotensinogen (AGT) gene was found to be associated with infants small for gestational age (SGA). The present study of 107 pregnancies affected by SGA infants and 101 normal pregnancies was designed to further investigate this association. Maternal or fetal AGT genotype or haplotype frequencies did not differ between SGA and normal pregnancies (P > 0.35). Quantitative trait analysis of mothers with normal pregnancies demonstrated an association between AGT haplotype and blood pressure and body mass index at antenatal booking (P= 0.04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women. © RCOG 2006 BJOG An International Journal of Obstetrics and Gynaecology.

U2 - 10.1111/j.1471-0528.2005.00841.x

DO - 10.1111/j.1471-0528.2005.00841.x

M3 - Article

SN - 1471-0528

VL - 113

SP - 335

EP - 339

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

IS - 3

ER -

Angiotensinogen gene variants and small-for-gestational-age infants

Abstract

Access to Document

Fingerprint

Cite this