Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR antagonist MPPG

T. E. Salt, J. P. Turner

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The metabotropic glutamate receptor (mGluR) agonists CCG-I and L-AP4, acting at Group II and Group III mGluRs respectively, can reduce GABAergic synaptic inhibition on single neurones in the rat thalamus in vivo via a presumed presynaptic mechanism. The actions of L-AP4 were antagonized by (±)-α-methyl-4-phosphonophenylglycine (MPPG), whereas CCG-I was significantly less affected. Thus MPPG may be a useful tool for detecting physiological roles for Group III mGluRs.
    Original languageEnglish
    Pages (from-to)239-241
    Number of pages2
    JournalNeuropharmacology
    Volume35
    Issue number2
    DOIs
    Publication statusPublished - Feb 1996

    Keywords

    • CCG-I
    • GABA
    • L-AP4
    • mGluR
    • Sensory systems
    • Thalamus

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