Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

Gauri Deb; Tim C P Somervaille

doi:10.1016/j.ccell.2016.06.006

Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

Gauri Deb, Tim C P Somervaille

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Cancer Cell
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.ccell.2016.06.006
Publication status	Published - 11 Jul 2016

Keywords

Journal Article

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2016.06.006

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title = "Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage",

abstract = "E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.",

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AU - Somervaille, Tim C P

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N2 - E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.

AB - E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.

KW - Journal Article

U2 - 10.1016/j.ccell.2016.06.006

DO - 10.1016/j.ccell.2016.06.006

M3 - Article

C2 - 27411580

SN - 1535-6108

VL - 30

SP - 5

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JO - Cancer Cell

JF - Cancer Cell

IS - 1

ER -

Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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