Anterior cingulate and subgenual prefrontal blood flow changes following tryptophan depletion in healthy males

Peter Talbot; Peter S. Talbot; Stephen J. Cooper

doi:10.1038/sj.npp.1301022

Anterior cingulate and subgenual prefrontal blood flow changes following tryptophan depletion in healthy males

Peter Talbot, Peter S. Talbot, Stephen J. Cooper

Research output: Contribution to journal › Article › peer-review

Abstract

In healthy humans, there is an apparent dissociation between cognitive and affective consequences of reduced brain serotonin (5-HT), as rapid tryptophan depletion (RTD) causes alterations in a consistent constellation of cognitive processes in the general absence of mood deterioration. This study aimed to investigate possible neural mechanisms underlying this relative dissociation by measuring the effects of reduced 5-HT on regional cerebral blood flow (rCBF). A total of 16 healthy, euthymic male subjects (mean age 39±9 years) without a personal or family history of affective disorder had mood ratings and single photon emission computed tomography scans with the rCBF tracer 99mTc-HMPAO under reduced 5-HT (RTD) and control conditions. Across individuals, modest positive and negative changes in subjective happiness associated with RTD were significantly correlated with change of rCBF in a cluster comprising subgenual (affective) anterior cingulate cortex (ACC) and associated regions (Brodmann's area (BA) 25, posterior BA11 and 47, caudate nucleus and ventral striatum; SPM99 p

Original language	English
Pages (from-to)	1757-1767
Number of pages	10
Journal	Neuropsychopharmacology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1038/sj.npp.1301022
Publication status	Published - 9 Aug 2006

Keywords

99mTc-HMPAO
Anterior cingulate
Serotonin (5-HT)
Single photon emission computed tomography (SPECT)
Subgenual refrontal cortex
Tryptophan depletion

Access to Document

10.1038/sj.npp.1301022

Cite this

@article{7733848cbe1c4216a451f6d0dbc0d701,

title = "Anterior cingulate and subgenual prefrontal blood flow changes following tryptophan depletion in healthy males",

abstract = "In healthy humans, there is an apparent dissociation between cognitive and affective consequences of reduced brain serotonin (5-HT), as rapid tryptophan depletion (RTD) causes alterations in a consistent constellation of cognitive processes in the general absence of mood deterioration. This study aimed to investigate possible neural mechanisms underlying this relative dissociation by measuring the effects of reduced 5-HT on regional cerebral blood flow (rCBF). A total of 16 healthy, euthymic male subjects (mean age 39±9 years) without a personal or family history of affective disorder had mood ratings and single photon emission computed tomography scans with the rCBF tracer 99mTc-HMPAO under reduced 5-HT (RTD) and control conditions. Across individuals, modest positive and negative changes in subjective happiness associated with RTD were significantly correlated with change of rCBF in a cluster comprising subgenual (affective) anterior cingulate cortex (ACC) and associated regions (Brodmann's area (BA) 25, posterior BA11 and 47, caudate nucleus and ventral striatum; SPM99 p",

keywords = "99mTc-HMPAO, Anterior cingulate, Serotonin (5-HT), Single photon emission computed tomography (SPECT), Subgenual refrontal cortex, Tryptophan depletion",

author = "Peter Talbot and Talbot, {Peter S.} and Cooper, {Stephen J.}",

year = "2006",

month = aug,

day = "9",

doi = "10.1038/sj.npp.1301022",

language = "English",

volume = "31",

pages = "1757--1767",

journal = "Neuropsychopharmacology",

publisher = "Springer Nature",

number = "8",

}

TY - JOUR

T1 - Anterior cingulate and subgenual prefrontal blood flow changes following tryptophan depletion in healthy males

AU - Talbot, Peter

AU - Talbot, Peter S.

AU - Cooper, Stephen J.

PY - 2006/8/9

Y1 - 2006/8/9

N2 - In healthy humans, there is an apparent dissociation between cognitive and affective consequences of reduced brain serotonin (5-HT), as rapid tryptophan depletion (RTD) causes alterations in a consistent constellation of cognitive processes in the general absence of mood deterioration. This study aimed to investigate possible neural mechanisms underlying this relative dissociation by measuring the effects of reduced 5-HT on regional cerebral blood flow (rCBF). A total of 16 healthy, euthymic male subjects (mean age 39±9 years) without a personal or family history of affective disorder had mood ratings and single photon emission computed tomography scans with the rCBF tracer 99mTc-HMPAO under reduced 5-HT (RTD) and control conditions. Across individuals, modest positive and negative changes in subjective happiness associated with RTD were significantly correlated with change of rCBF in a cluster comprising subgenual (affective) anterior cingulate cortex (ACC) and associated regions (Brodmann's area (BA) 25, posterior BA11 and 47, caudate nucleus and ventral striatum; SPM99 p

AB - In healthy humans, there is an apparent dissociation between cognitive and affective consequences of reduced brain serotonin (5-HT), as rapid tryptophan depletion (RTD) causes alterations in a consistent constellation of cognitive processes in the general absence of mood deterioration. This study aimed to investigate possible neural mechanisms underlying this relative dissociation by measuring the effects of reduced 5-HT on regional cerebral blood flow (rCBF). A total of 16 healthy, euthymic male subjects (mean age 39±9 years) without a personal or family history of affective disorder had mood ratings and single photon emission computed tomography scans with the rCBF tracer 99mTc-HMPAO under reduced 5-HT (RTD) and control conditions. Across individuals, modest positive and negative changes in subjective happiness associated with RTD were significantly correlated with change of rCBF in a cluster comprising subgenual (affective) anterior cingulate cortex (ACC) and associated regions (Brodmann's area (BA) 25, posterior BA11 and 47, caudate nucleus and ventral striatum; SPM99 p

KW - 99mTc-HMPAO

KW - Anterior cingulate

KW - Serotonin (5-HT)

KW - Single photon emission computed tomography (SPECT)

KW - Subgenual refrontal cortex

KW - Tryptophan depletion

U2 - 10.1038/sj.npp.1301022

DO - 10.1038/sj.npp.1301022

M3 - Article

VL - 31

SP - 1757

EP - 1767

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 8

ER -

Anterior cingulate and subgenual prefrontal blood flow changes following tryptophan depletion in healthy males

Abstract

Keywords

Access to Document

Fingerprint

Cite this