Anti-C1q antibodies in systemic lupus erythematosus.

A-M Orbai, L Truedsson, G Sturfelt, O Nived, H Fang, Gs Alarcón, C Gordon, Jt Merrill, Pr Fortin, In Bruce, DA Isenberg, Dj Wallace, R Ramsey-Goldman, S-C Bae, Jg Hanly, J Sanchez-Guerrero, Ae Clarke, Cb Aranow, S Manzi, Mb UrowitzDd Gladman, Kc Kalunian, Mi Costner, Vp Werth, A Zoma, S Bernatsky, G Ruiz-Irastorza, Ma Khamashta, S Jacobsen, Jp Buyon, P Maddison, Ma Dooley, Rf Van Vollenhoven, E Ginzler, T Stoll, C Peschken, Jl Jorizzo, Jp Callen, Ss Lim, Bj Fessler, M Inanc, Dl Kamen, A Rahman, K Steinsson, Ag Franks, L Sigler, S Hameed, N Pham, R Brey, Mh Weisman, G McGwin, Ls Magder, M Petri

    Research output: Contribution to journalArticlepeer-review


    OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. RESULTS: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p 
    Original languageEnglish
    Pages (from-to)42-49
    Number of pages7
    Issue number1
    Publication statusPublished - 2015


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