Anti-C1q antibodies in systemic lupus erythematosus.

A-M Orbai; L Truedsson; G Sturfelt; O Nived; H Fang; Gs Alarcón; C Gordon; Jt Merrill; Pr Fortin; In Bruce; DA Isenberg; Dj Wallace; R Ramsey-Goldman; S-C Bae; Jg Hanly; J Sanchez-Guerrero; Ae Clarke; Cb Aranow; S Manzi; Mb Urowitz; Dd Gladman; Kc Kalunian; Mi Costner; Vp Werth; A Zoma; S Bernatsky; G Ruiz-Irastorza; Ma Khamashta; S Jacobsen; Jp Buyon; P Maddison; Ma Dooley; Rf Van Vollenhoven; E Ginzler; T Stoll; C Peschken; Jl Jorizzo; Jp Callen; Ss Lim; Bj Fessler; M Inanc; Dl Kamen; A Rahman; K Steinsson; Ag Franks; L Sigler; S Hameed; N Pham; R Brey; Mh Weisman; G McGwin; Ls Magder; M Petri

doi:10.1177/0961203314547791

Anti-C1q antibodies in systemic lupus erythematosus.

A-M Orbai, L Truedsson, G Sturfelt, O Nived, H Fang, Gs Alarcón, C Gordon, Jt Merrill, Pr Fortin, In Bruce, DA Isenberg, Dj Wallace, R Ramsey-Goldman, S-C Bae, Jg Hanly, J Sanchez-Guerrero, Ae Clarke, Cb Aranow, S Manzi, Mb UrowitzDd Gladman, Kc Kalunian, Mi Costner, Vp Werth, A Zoma, S Bernatsky, G Ruiz-Irastorza, Ma Khamashta, S Jacobsen, Jp Buyon, P Maddison, Ma Dooley, Rf Van Vollenhoven, E Ginzler, T Stoll, C Peschken, Jl Jorizzo, Jp Callen, Ss Lim, Bj Fessler, M Inanc, Dl Kamen, A Rahman, K Steinsson, Ag Franks, L Sigler, S Hameed, N Pham, R Brey, Mh Weisman, G McGwin, Ls Magder, M Petri

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. RESULTS: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p

Original language	English
Pages (from-to)	42-49
Number of pages	7
Journal	Lupus
Volume	24
Issue number	1
DOIs	https://doi.org/10.1177/0961203314547791
Publication status	Published - 2015

Keywords

Anti-dsDNA antibodies
renal lupus
systemic lupus erythematosus

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10.1177/0961203314547791

Arthritis Research UK Centre of Excellence in Epidemiology.
Symmons, D. (PI), Bruce, I. (CoI), Dixon, W. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI) & Verstappen, S. (CoI)
1/08/13 → 31/07/18
Project: Research

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Orbai, A.-M., Truedsson, L., Sturfelt, G., Nived, O., Fang, H., Alarcón, G., Gordon, C., Merrill, J., Fortin, P., Bruce, I., Isenberg, DA., Wallace, D., Ramsey-Goldman, R., Bae, S.-C., Hanly, J., Sanchez-Guerrero, J., Clarke, A., Aranow, C., Manzi, S., ... Petri, M. (2015). Anti-C1q antibodies in systemic lupus erythematosus. Lupus, 24(1), 42-49. https://doi.org/10.1177/0961203314547791

@article{42824e488aae488c9c264b5065d94e00,

title = "Anti-C1q antibodies in systemic lupus erythematosus.",

abstract = "OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. RESULTS: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p ",

keywords = "Anti-dsDNA antibodies, renal lupus, systemic lupus erythematosus",

author = "A-M Orbai and L Truedsson and G Sturfelt and O Nived and H Fang and Gs Alarc{\'o}n and C Gordon and Jt Merrill and Pr Fortin and In Bruce and DA Isenberg and Dj Wallace and R Ramsey-Goldman and S-C Bae and Jg Hanly and J Sanchez-Guerrero and Ae Clarke and Cb Aranow and S Manzi and Mb Urowitz and Dd Gladman and Kc Kalunian and Mi Costner and Vp Werth and A Zoma and S Bernatsky and G Ruiz-Irastorza and Ma Khamashta and S Jacobsen and Jp Buyon and P Maddison and Ma Dooley and {Van Vollenhoven}, Rf and E Ginzler and T Stoll and C Peschken and Jl Jorizzo and Jp Callen and Ss Lim and Bj Fessler and M Inanc and Dl Kamen and A Rahman and K Steinsson and Ag Franks and L Sigler and S Hameed and N Pham and R Brey and Mh Weisman and G McGwin and Ls Magder and M Petri",

note = "U01 AR051871, NIAMS NIH HHS, United States",

year = "2015",

doi = "10.1177/0961203314547791",

language = "English",

volume = "24",

pages = "42--49",

journal = "Lupus",

issn = "1477-0962",

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number = "1",

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Orbai, A-M, Truedsson, L, Sturfelt, G, Nived, O, Fang, H, Alarcón, G, Gordon, C, Merrill, J, Fortin, P, Bruce, I, Isenberg, DA, Wallace, D, Ramsey-Goldman, R, Bae, S-C, Hanly, J, Sanchez-Guerrero, J, Clarke, A, Aranow, C, Manzi, S, Urowitz, M, Gladman, D, Kalunian, K, Costner, M, Werth, V, Zoma, A, Bernatsky, S, Ruiz-Irastorza, G, Khamashta, M, Jacobsen, S, Buyon, J, Maddison, P, Dooley, M, Van Vollenhoven, R, Ginzler, E, Stoll, T, Peschken, C, Jorizzo, J, Callen, J, Lim, S, Fessler, B, Inanc, M, Kamen, D, Rahman, A, Steinsson, K, Franks, A, Sigler, L, Hameed, S, Pham, N, Brey, R, Weisman, M, McGwin, G, Magder, L & Petri, M 2015, 'Anti-C1q antibodies in systemic lupus erythematosus.', Lupus, vol. 24, no. 1, pp. 42-49. https://doi.org/10.1177/0961203314547791

TY - JOUR

T1 - Anti-C1q antibodies in systemic lupus erythematosus.

AU - Orbai, A-M

AU - Truedsson, L

AU - Sturfelt, G

AU - Nived, O

AU - Fang, H

AU - Alarcón, Gs

AU - Gordon, C

AU - Merrill, Jt

AU - Fortin, Pr

AU - Bruce, In

AU - Isenberg, DA

AU - Wallace, Dj

AU - Ramsey-Goldman, R

AU - Bae, S-C

AU - Hanly, Jg

AU - Sanchez-Guerrero, J

AU - Clarke, Ae

AU - Aranow, Cb

AU - Manzi, S

AU - Urowitz, Mb

AU - Gladman, Dd

AU - Kalunian, Kc

AU - Costner, Mi

AU - Werth, Vp

AU - Zoma, A

AU - Bernatsky, S

AU - Ruiz-Irastorza, G

AU - Khamashta, Ma

AU - Jacobsen, S

AU - Buyon, Jp

AU - Maddison, P

AU - Dooley, Ma

AU - Van Vollenhoven, Rf

AU - Ginzler, E

AU - Stoll, T

AU - Peschken, C

AU - Jorizzo, Jl

AU - Callen, Jp

AU - Lim, Ss

AU - Fessler, Bj

AU - Inanc, M

AU - Kamen, Dl

AU - Rahman, A

AU - Steinsson, K

AU - Franks, Ag

AU - Sigler, L

AU - Hameed, S

AU - Pham, N

AU - Brey, R

AU - Weisman, Mh

AU - McGwin, G

AU - Magder, Ls

AU - Petri, M

N1 - U01 AR051871, NIAMS NIH HHS, United States

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. RESULTS: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p

AB - OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. RESULTS: Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p

KW - Anti-dsDNA antibodies

KW - renal lupus

KW - systemic lupus erythematosus

U2 - 10.1177/0961203314547791

DO - 10.1177/0961203314547791

M3 - Article

C2 - 25124676

SN - 1477-0962

VL - 24

SP - 42

EP - 49

JO - Lupus

JF - Lupus

IS - 1

ER -

Anti-C1q antibodies in systemic lupus erythematosus.

Abstract

Keywords

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Arthritis Research UK Centre of Excellence in Epidemiology.

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