Anti-fungal target genes

Danny Tuckwell (Other), Michael Bromley (Other)

Research output: Patent


Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 74, 78, 82, 86 or 90 (ii) a protein which has 50% identity with (i), (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, (iv) a polynucleotide that comprises sequence which encodes (i), (ii) or (iii), (v) a polynucleotide comprising sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent.
Original languageEnglish
Patent numberWO 2005095975 A2
Publication statusPublished - 13 Oct 2005


Dive into the research topics of 'Anti-fungal target genes'. Together they form a unique fingerprint.

Cite this