Anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone)

Marília Maria Sitônio, Carlson Carvalho Junior, Ingrid de Araújo Campos, José Bruno Nunes Ferreira da Silva, Maria do Carmo Alves de Lima, Alexandre J. S. Góes, Maria Bernadete Sousa Maia, Pedro J. Rolim Neto

Research output: Contribution to journalArticlepeer-review

Abstract

Objective and design: The purpose of this study was to evaluate the anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone; β-lap) and to elucidate its probable mode of action.

Methods: Carrageenan-induced paw edema, cell migration evaluation and production of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-6 and nitric oxide were used for this study. Freund’s complete adjuvant (FCA)-induced arthritis was used as a model of chronic inflammation. β-Lap was tested in doses of 40 and 60 mg/kg, orally.

Results: In the paw edema test, the dose of 60 mg/kg gave a higher percentage inhibition of edema (49.3 %) than control. β-Lap inhibited neutrophil migration and reduced concentrations of TNF-α, IL-6 and NO in peritoneal exudates of animals with peritonitis. In the arthritis test, β-lap inhibited edema and NO production in the serum of treated animals.

Conclusion: Significant anti-inflammatory and anti-arthritic activities were observed in animals treated with β-lap. The effects of β-lap can be attributed in part to immunomodulation with reduction of pro-inflammatory cytokines and NO.
Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalInflammation Research
Volume62
Early online date28 Sept 2012
DOIs
Publication statusPublished - Jan 2013

Keywords

  • cytokines
  • leukocyte migration
  • inflammatory mediators
  • arthritis

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