Antibacterial activity of sucralfate against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in batch and continuous culture

A. P. West; S. Abdul; M. J. Sherratt; T. J J Inglis

doi:10.1007/BF02000412

Antibacterial activity of sucralfate against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in batch and continuous culture

A. P. West, S. Abdul, M. J. Sherratt, T. J J Inglis

Research output: Contribution to journal › Article › peer-review

Abstract

The antibacterial effect of varying concentrations of sucralfate was studied on Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus grown in both agitated batch and continuous culture. The minimum inhibitory concentrations estimated with the two methods were in close agreement, ranging from 5 to 15 mg sucralfate/ml, concentrations easily attainable in gastric juice after a standard adult dose. Batch culture results indicated a dose-dependent effect. This study provides further evidence for an antibacterial effect by sucralfate against a range of species associated with respiratory tract infection in ventilated patients. © 1993 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

Original language	English
Pages (from-to)	869-871
Number of pages	2
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	12
Issue number	11
DOIs	https://doi.org/10.1007/BF02000412
Publication status	Published - Nov 1993

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10.1007/BF02000412

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title = "Antibacterial activity of sucralfate against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in batch and continuous culture",

abstract = "The antibacterial effect of varying concentrations of sucralfate was studied on Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus grown in both agitated batch and continuous culture. The minimum inhibitory concentrations estimated with the two methods were in close agreement, ranging from 5 to 15 mg sucralfate/ml, concentrations easily attainable in gastric juice after a standard adult dose. Batch culture results indicated a dose-dependent effect. This study provides further evidence for an antibacterial effect by sucralfate against a range of species associated with respiratory tract infection in ventilated patients. {\textcopyright} 1993 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.",

author = "West, {A. P.} and S. Abdul and Sherratt, {M. J.} and Inglis, {T. J J}",

year = "1993",

month = nov,

doi = "10.1007/BF02000412",

language = "English",

volume = "12",

pages = "869--871",

journal = "European Journal of Clinical Microbiology and Infectious Diseases",

issn = "0934-9723",

publisher = "Springer Nature",

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}

Antibacterial activity of sucralfate against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in batch and continuous culture. / West, A. P.; Abdul, S.; Sherratt, M. J. et al.
In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 12, No. 11, 11.1993, p. 869-871.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Antibacterial activity of sucralfate against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in batch and continuous culture

AU - West, A. P.

AU - Abdul, S.

AU - Sherratt, M. J.

AU - Inglis, T. J J

PY - 1993/11

Y1 - 1993/11

N2 - The antibacterial effect of varying concentrations of sucralfate was studied on Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus grown in both agitated batch and continuous culture. The minimum inhibitory concentrations estimated with the two methods were in close agreement, ranging from 5 to 15 mg sucralfate/ml, concentrations easily attainable in gastric juice after a standard adult dose. Batch culture results indicated a dose-dependent effect. This study provides further evidence for an antibacterial effect by sucralfate against a range of species associated with respiratory tract infection in ventilated patients. © 1993 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

AB - The antibacterial effect of varying concentrations of sucralfate was studied on Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus grown in both agitated batch and continuous culture. The minimum inhibitory concentrations estimated with the two methods were in close agreement, ranging from 5 to 15 mg sucralfate/ml, concentrations easily attainable in gastric juice after a standard adult dose. Batch culture results indicated a dose-dependent effect. This study provides further evidence for an antibacterial effect by sucralfate against a range of species associated with respiratory tract infection in ventilated patients. © 1993 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

U2 - 10.1007/BF02000412

DO - 10.1007/BF02000412

M3 - Article

SN - 0934-9723

VL - 12

SP - 869

EP - 871

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

IS - 11

ER -

Antibacterial activity of sucralfate against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa in batch and continuous culture

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