Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin a hybrid peptide

Malcolm Richardson; David Wade; Jan Ingmar Flock; Charlotta Edlund; Ingegerd Löfving-Arvholm; Matti Sällberg; Tomas Bergman; Angela Silveira; Cecille Unson; Louise Rollins-Smith; Jerzy Silberring; Malcom Richardson; Pentti Kuusela; Hilkka Lankinen

doi:10.2174/0929866023408409

Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin a hybrid peptide

Malcolm Richardson, David Wade, Jan Ingmar Flock, Charlotta Edlund, Ingegerd Löfving-Arvholm, Matti Sällberg, Tomas Bergman, Angela Silveira, Cecille Unson, Louise Rollins-Smith, Jerzy Silberring, Malcom Richardson, Pentti Kuusela, Hilkka Lankinen

Research output: Contribution to journal › Article › peer-review

Abstract

Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.

Original language	English
Pages (from-to)	533-543
Number of pages	10
Journal	Protein and Peptide Letters
Volume	9
Issue number	6
DOIs	https://doi.org/10.2174/0929866023408409
Publication status	Published - 2002

Keywords

Antibiotic peptides
Antibiotic resistant bacteria
Antifungal
Cecropin A
Hemolysis
Human erythrocyte lysis
Ranatuerin 6
Temporin A
VesCP-M

Access to Document

10.2174/0929866023408409

Cite this

Richardson, M., Wade, D., Flock, J. I., Edlund, C., Löfving-Arvholm, I., Sällberg, M., Bergman, T., Silveira, A., Unson, C., Rollins-Smith, L., Silberring, J., Richardson, M., Kuusela, P., & Lankinen, H. (2002). Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin a hybrid peptide. Protein and Peptide Letters, 9(6), 533-543. https://doi.org/10.2174/0929866023408409

@article{89dfc566f8894d2e9766105c385586cd,

title = "Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin a hybrid peptide",

abstract = "Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.",

keywords = "Antibiotic peptides, Antibiotic resistant bacteria, Antifungal, Cecropin A, Hemolysis, Human erythrocyte lysis, Ranatuerin 6, Temporin A, VesCP-M",

author = "Malcolm Richardson and David Wade and Flock, {Jan Ingmar} and Charlotta Edlund and Ingegerd L{\"o}fving-Arvholm and Matti S{\"a}llberg and Tomas Bergman and Angela Silveira and Cecille Unson and Louise Rollins-Smith and Jerzy Silberring and Malcom Richardson and Pentti Kuusela and Hilkka Lankinen",

year = "2002",

doi = "10.2174/0929866023408409",

language = "English",

volume = "9",

pages = "533--543",

journal = "Protein and Peptide Letters",

publisher = "Bentham Science Publishers",

number = "6",

}

Richardson, M, Wade, D, Flock, JI, Edlund, C, Löfving-Arvholm, I, Sällberg, M, Bergman, T, Silveira, A, Unson, C, Rollins-Smith, L, Silberring, J, Richardson, M, Kuusela, P & Lankinen, H 2002, 'Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin a hybrid peptide', Protein and Peptide Letters, vol. 9, no. 6, pp. 533-543. https://doi.org/10.2174/0929866023408409

TY - JOUR

T1 - Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin a hybrid peptide

AU - Richardson, Malcolm

AU - Wade, David

AU - Flock, Jan Ingmar

AU - Edlund, Charlotta

AU - Löfving-Arvholm, Ingegerd

AU - Sällberg, Matti

AU - Bergman, Tomas

AU - Silveira, Angela

AU - Unson, Cecille

AU - Rollins-Smith, Louise

AU - Silberring, Jerzy

AU - Richardson, Malcom

AU - Kuusela, Pentti

AU - Lankinen, Hilkka

PY - 2002

Y1 - 2002

N2 - Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.

AB - Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.

KW - Antibiotic peptides

KW - Antibiotic resistant bacteria

KW - Antifungal

KW - Cecropin A

KW - Hemolysis

KW - Human erythrocyte lysis

KW - Ranatuerin 6

KW - Temporin A

KW - VesCP-M

U2 - 10.2174/0929866023408409

DO - 10.2174/0929866023408409

M3 - Article

C2 - 12553862

VL - 9

SP - 533

EP - 543

JO - Protein and Peptide Letters

JF - Protein and Peptide Letters

IS - 6

ER -

Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin a hybrid peptide

Abstract

Keywords

Access to Document

Fingerprint

Cite this