Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Tim Waterboer; Kristina M. Michael; Peter Sehr; Maurits N C De Koning; Sönke J. Weißenborn; Francesca Sampogna; Damiano Abeni; Adele C. Green; Jan Nico Bouwes Bavinck; Michael Pawlita; P. van der Zwan-Kralt; Y. G L de Graaf; L. E. Vos; E. J. Uphoff-Meijerink; R. Willemze; M. C W Feltkamp; L. Struijk; P. Wanningen; P. Z. van der Meijen; E. I. Plasmeijer; R. Wolterbeek; S. Euvrard; A. C. Butnaru; A. Claudy; J. Kanitakis; I. Nindl; E. Stockflelt; T. Forschner; L. Naldi; A. Pizzagali; F. Sassi; G. Tessari; C. A. Harwood; C. M. Proby; J. Breuer; L. Mitchell; K. Purdie; S. R. Lambert; H. Ran; H. Pfister; U. Wieland; W. G V Quint; J. ter Schegget; B. Kleter; L. J. van Doorn; T. J. Mannooranparampil; N. Melo-Salcedo; S. Simoni; Petasecca G P Donati; C. Masini; Deppermann C. Fortes; A. C. Green; R. Neale; C. Olsen; P. O'Rourke; K. A. Mallitt; S. Harrison; P. Buttner

doi:10.1099/vir.0.010637-0

Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Tim Waterboer, Kristina M. Michael, Peter Sehr, Maurits N C De Koning, Sönke J. Weißenborn, Francesca Sampogna, Damiano Abeni, Adele C. Green, Jan Nico Bouwes Bavinck, Michael Pawlita, P. van der Zwan-Kralt, Y. G L de Graaf, L. E. Vos, E. J. Uphoff-Meijerink, R. Willemze, M. C W Feltkamp, L. Struijk, P. Wanningen, P. Z. van der Meijen, E. I. PlasmeijerR. Wolterbeek, S. Euvrard, A. C. Butnaru, A. Claudy, J. Kanitakis, I. Nindl, E. Stockflelt, T. Forschner, L. Naldi, A. Pizzagali, F. Sassi, G. Tessari, C. A. Harwood, C. M. Proby, J. Breuer, L. Mitchell, K. Purdie, S. R. Lambert, H. Ran, H. Pfister, U. Wieland, W. G V Quint, J. ter Schegget, B. Kleter, L. J. van Doorn, T. J. Mannooranparampil, N. Melo-Salcedo, S. Simoni, Petasecca G P Donati, C. Masini, Deppermann C. Fortes, A. C. Green, R. Neale, C. Olsen, P. O'Rourke, K. A. Mallitt, S. Harrison, P. Buttner

Research output: Contribution to journal › Article › peer-review

Abstract

Solar UV radiation is the main risk factor for cutaneous squamous cell carcinoma (SCC), but infections with skin human papillomavirus (HPV) types have also been linked to the development of SCC. Little is known about the natural history of these infections and whether the seroprevalence of skin HPV types is affected by ambient or individual levels of sun exposure. This study investigated this by analysing sera for antibodies to 26 skin HPV types from five phylogenetic genera obtained from 807 healthy individuals from the Netherlands, Italy and Australia, countries with strong differences in sunlight intensity. Overall HPV seroprevalence was similar across the three countries (50-57% for β-HPV types, 40-48% for γ-HPV types), and the most frequent β-HPV and γ-HPV types were the same in all countries. The highest seroprevalences for 24 of the 26 skin HPV types were observed in Italy (14 types) and Australia (ten types). Seroprevalence among men was generally higher than among women, and the male sex was significantly associated with both β-HPV [odds ratio (OR) 2.81, 95% confidence interval (CI) 1.64-4.82] and γ-HPV (OR 2.42, 95% CI 1.40-4.18) antibodies in Australia. The only measure of sun sensitivity or UV exposure significantly associated with skin HPV seroprevalence was found for weekend sun exposure in Australia and β-HPV antibodies. It was concluded that type spectra and HPV seroprevalence are similar in countries with different sunlight intensity, and that levels of UV exposure do not play a strong role in the development of skin HPV antibodies in this study population. © 2009 SGM.

Original language	English
Pages (from-to)	1986-1998
Number of pages	12
Journal	Journal of General Virology
Volume	90
Issue number	8
DOIs	https://doi.org/10.1099/vir.0.010637-0
Publication status	Published - 2009

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10.1099/vir.0.010637-0

http://vir.sgmjournals.org/cgi/reprint/90/8/1986

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Waterboer, T., Michael, K. M., Sehr, P., De Koning, M. N. C., Weißenborn, S. J., Sampogna, F., Abeni, D., Green, A. C., Bavinck, J. N. B., Pawlita, M., van der Zwan-Kralt, P., de Graaf, Y. G. L., Vos, L. E., Uphoff-Meijerink, E. J., Willemze, R., Feltkamp, M. C. W., Struijk, L., Wanningen, P., van der Meijen, P. Z., ... Buttner, P. (2009). Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia. Journal of General Virology, 90(8), 1986-1998. https://doi.org/10.1099/vir.0.010637-0

@article{02a5ac6a73004b94a24acff6fa483f72,

title = "Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia",

abstract = "Solar UV radiation is the main risk factor for cutaneous squamous cell carcinoma (SCC), but infections with skin human papillomavirus (HPV) types have also been linked to the development of SCC. Little is known about the natural history of these infections and whether the seroprevalence of skin HPV types is affected by ambient or individual levels of sun exposure. This study investigated this by analysing sera for antibodies to 26 skin HPV types from five phylogenetic genera obtained from 807 healthy individuals from the Netherlands, Italy and Australia, countries with strong differences in sunlight intensity. Overall HPV seroprevalence was similar across the three countries (50-57% for β-HPV types, 40-48% for γ-HPV types), and the most frequent β-HPV and γ-HPV types were the same in all countries. The highest seroprevalences for 24 of the 26 skin HPV types were observed in Italy (14 types) and Australia (ten types). Seroprevalence among men was generally higher than among women, and the male sex was significantly associated with both β-HPV [odds ratio (OR) 2.81, 95% confidence interval (CI) 1.64-4.82] and γ-HPV (OR 2.42, 95% CI 1.40-4.18) antibodies in Australia. The only measure of sun sensitivity or UV exposure significantly associated with skin HPV seroprevalence was found for weekend sun exposure in Australia and β-HPV antibodies. It was concluded that type spectra and HPV seroprevalence are similar in countries with different sunlight intensity, and that levels of UV exposure do not play a strong role in the development of skin HPV antibodies in this study population. {\textcopyright} 2009 SGM.",

author = "Tim Waterboer and Michael, {Kristina M.} and Peter Sehr and {De Koning}, {Maurits N C} and Wei{\ss}enborn, {S{\"o}nke J.} and Francesca Sampogna and Damiano Abeni and Green, {Adele C.} and Bavinck, {Jan Nico Bouwes} and Michael Pawlita and {van der Zwan-Kralt}, P. and {de Graaf}, {Y. G L} and Vos, {L. E.} and Uphoff-Meijerink, {E. J.} and R. Willemze and Feltkamp, {M. C W} and L. Struijk and P. Wanningen and {van der Meijen}, {P. Z.} and Plasmeijer, {E. I.} and R. Wolterbeek and S. Euvrard and Butnaru, {A. C.} and A. Claudy and J. Kanitakis and I. Nindl and E. Stockflelt and T. Forschner and L. Naldi and A. Pizzagali and F. Sassi and G. Tessari and Harwood, {C. A.} and Proby, {C. M.} and J. Breuer and L. Mitchell and K. Purdie and Lambert, {S. R.} and H. Ran and H. Pfister and U. Wieland and Quint, {W. G V} and {ter Schegget}, J. and B. Kleter and {van Doorn}, {L. J.} and Mannooranparampil, {T. J.} and N. Melo-Salcedo and S. Simoni and Donati, {Petasecca G P} and C. Masini and Fortes, {Deppermann C.} and Green, {A. C.} and R. Neale and C. Olsen and P. O'Rourke and Mallitt, {K. A.} and S. Harrison and P. Buttner",

year = "2009",

doi = "10.1099/vir.0.010637-0",

language = "English",

volume = "90",

pages = "1986--1998",

journal = "Journal of General Virology",

issn = "1465-2099",

publisher = "Microbiology Society",

number = "8",

}

Waterboer, T, Michael, KM, Sehr, P, De Koning, MNC, Weißenborn, SJ, Sampogna, F, Abeni, D, Green, AC, Bavinck, JNB, Pawlita, M, van der Zwan-Kralt, P, de Graaf, YGL, Vos, LE, Uphoff-Meijerink, EJ, Willemze, R, Feltkamp, MCW, Struijk, L, Wanningen, P, van der Meijen, PZ, Plasmeijer, EI, Wolterbeek, R, Euvrard, S, Butnaru, AC, Claudy, A, Kanitakis, J, Nindl, I, Stockflelt, E, Forschner, T, Naldi, L, Pizzagali, A, Sassi, F, Tessari, G, Harwood, CA, Proby, CM, Breuer, J, Mitchell, L, Purdie, K, Lambert, SR, Ran, H, Pfister, H, Wieland, U, Quint, WGV, ter Schegget, J, Kleter, B, van Doorn, LJ, Mannooranparampil, TJ, Melo-Salcedo, N, Simoni, S, Donati, PGP, Masini, C, Fortes, DC, Green, AC, Neale, R, Olsen, C, O'Rourke, P, Mallitt, KA, Harrison, S & Buttner, P 2009, 'Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia', Journal of General Virology, vol. 90, no. 8, pp. 1986-1998. https://doi.org/10.1099/vir.0.010637-0

TY - JOUR

T1 - Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

AU - Waterboer, Tim

AU - Michael, Kristina M.

AU - Sehr, Peter

AU - De Koning, Maurits N C

AU - Weißenborn, Sönke J.

AU - Sampogna, Francesca

AU - Abeni, Damiano

AU - Green, Adele C.

AU - Bavinck, Jan Nico Bouwes

AU - Pawlita, Michael

AU - van der Zwan-Kralt, P.

AU - de Graaf, Y. G L

AU - Vos, L. E.

AU - Uphoff-Meijerink, E. J.

AU - Willemze, R.

AU - Feltkamp, M. C W

AU - Struijk, L.

AU - Wanningen, P.

AU - van der Meijen, P. Z.

AU - Plasmeijer, E. I.

AU - Wolterbeek, R.

AU - Euvrard, S.

AU - Butnaru, A. C.

AU - Claudy, A.

AU - Kanitakis, J.

AU - Nindl, I.

AU - Stockflelt, E.

AU - Forschner, T.

AU - Naldi, L.

AU - Pizzagali, A.

AU - Sassi, F.

AU - Tessari, G.

AU - Harwood, C. A.

AU - Proby, C. M.

AU - Breuer, J.

AU - Mitchell, L.

AU - Purdie, K.

AU - Lambert, S. R.

AU - Ran, H.

AU - Pfister, H.

AU - Wieland, U.

AU - Quint, W. G V

AU - ter Schegget, J.

AU - Kleter, B.

AU - van Doorn, L. J.

AU - Mannooranparampil, T. J.

AU - Melo-Salcedo, N.

AU - Simoni, S.

AU - Donati, Petasecca G P

AU - Masini, C.

AU - Fortes, Deppermann C.

AU - Green, A. C.

AU - Neale, R.

AU - Olsen, C.

AU - O'Rourke, P.

AU - Mallitt, K. A.

AU - Harrison, S.

AU - Buttner, P.

PY - 2009

Y1 - 2009

N2 - Solar UV radiation is the main risk factor for cutaneous squamous cell carcinoma (SCC), but infections with skin human papillomavirus (HPV) types have also been linked to the development of SCC. Little is known about the natural history of these infections and whether the seroprevalence of skin HPV types is affected by ambient or individual levels of sun exposure. This study investigated this by analysing sera for antibodies to 26 skin HPV types from five phylogenetic genera obtained from 807 healthy individuals from the Netherlands, Italy and Australia, countries with strong differences in sunlight intensity. Overall HPV seroprevalence was similar across the three countries (50-57% for β-HPV types, 40-48% for γ-HPV types), and the most frequent β-HPV and γ-HPV types were the same in all countries. The highest seroprevalences for 24 of the 26 skin HPV types were observed in Italy (14 types) and Australia (ten types). Seroprevalence among men was generally higher than among women, and the male sex was significantly associated with both β-HPV [odds ratio (OR) 2.81, 95% confidence interval (CI) 1.64-4.82] and γ-HPV (OR 2.42, 95% CI 1.40-4.18) antibodies in Australia. The only measure of sun sensitivity or UV exposure significantly associated with skin HPV seroprevalence was found for weekend sun exposure in Australia and β-HPV antibodies. It was concluded that type spectra and HPV seroprevalence are similar in countries with different sunlight intensity, and that levels of UV exposure do not play a strong role in the development of skin HPV antibodies in this study population. © 2009 SGM.

AB - Solar UV radiation is the main risk factor for cutaneous squamous cell carcinoma (SCC), but infections with skin human papillomavirus (HPV) types have also been linked to the development of SCC. Little is known about the natural history of these infections and whether the seroprevalence of skin HPV types is affected by ambient or individual levels of sun exposure. This study investigated this by analysing sera for antibodies to 26 skin HPV types from five phylogenetic genera obtained from 807 healthy individuals from the Netherlands, Italy and Australia, countries with strong differences in sunlight intensity. Overall HPV seroprevalence was similar across the three countries (50-57% for β-HPV types, 40-48% for γ-HPV types), and the most frequent β-HPV and γ-HPV types were the same in all countries. The highest seroprevalences for 24 of the 26 skin HPV types were observed in Italy (14 types) and Australia (ten types). Seroprevalence among men was generally higher than among women, and the male sex was significantly associated with both β-HPV [odds ratio (OR) 2.81, 95% confidence interval (CI) 1.64-4.82] and γ-HPV (OR 2.42, 95% CI 1.40-4.18) antibodies in Australia. The only measure of sun sensitivity or UV exposure significantly associated with skin HPV seroprevalence was found for weekend sun exposure in Australia and β-HPV antibodies. It was concluded that type spectra and HPV seroprevalence are similar in countries with different sunlight intensity, and that levels of UV exposure do not play a strong role in the development of skin HPV antibodies in this study population. © 2009 SGM.

U2 - 10.1099/vir.0.010637-0

DO - 10.1099/vir.0.010637-0

M3 - Article

C2 - 19386782

SN - 1465-2099

VL - 90

SP - 1986

EP - 1998

JO - Journal of General Virology

JF - Journal of General Virology

IS - 8

ER -

Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia

Abstract

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