Antibody responses to single-dose SARS-CoV-2 vaccination in patients receiving immunomodulators for immune-mediated inflammatory disease

A Al-Janabi, Z Littlewood, C E M Griffiths, H J A Hunter, H Chinoy, C Moriarty, Z Z N Yiu, R B Warren

Research output: Contribution to journalLetterpeer-review

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Abstract

There are few data on whether immunomodulator therapy attenuates humoral response to vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some vaccines require two doses for maximum protection, with international variation in dosing schedules. A 3 month interval between doses is being used in the U.K. We evaluated antibody titres to SARS-CoV-2 following initial-dose BNT162b2 (Pfizer/BioNTech) or AZD1222 (AstraZeneca) vaccines in adults with psoriasis and other immune-mediated inflammatory diseases (IMIDs) receiving biologic and/or oral non-biologic immunomodulators.

Original languageEnglish
JournalThe British journal of dermatology
Early online date12 May 2021
DOIs
Publication statusPublished - 4 Jun 2021

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