Antibody to the gastric campylobacter-like organism ('Campylobacter pyloridis'): Clinical correlations and distribution in the normal population

D. M. Jones, J. Eldridge, A. J. Fox, P. Sethi, P. J. Whorwell

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Different cellular proteins of the gastric campylobacter-like organism (GCLO) were shown to be immunogenic for man. Antibodies to GCLO were detected in sera by both complement fixation and enzyme-linked immunoabsorbent assay. Antibody was found in 133 (52%) of 254 patients attending for gastroscopy. There was a high correlation between presence of antibody and a positive GCLO culture from the gastric mucus. Patients with normal endoscopic appearances, duodenal ulcer, duodenitis and oesophagitis had similar prevalences (c. 50%) of antibody. Only patients with endoscopically visible gastritis or gastric ulcer had a higher frequency (c. 80%) of antibody. In a normal population, antibody was uncommon in individuals
    Original languageEnglish
    Pages (from-to)57-62
    Number of pages5
    JournalJournal of medical microbiology
    Volume22
    Issue number1
    Publication statusPublished - 1986

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