Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361

Kaye Williams; Christopher R. Calabrese; Robert Almassy; Stephanie Barton; Michael A. Batey; A. Hilary Calvert; Stacie Canan-Koch; Barbara W. Durkacz; Zdenek Hostomsky; Robert A. Kumpf; Suzanne Kyle; Jianke Li; Karen Maegley; David R. Newell; Elena Notarianni; Ian J. Stratford; Donald Skalitzky; Huw D. Thomas; Lan Zhen Wang; Stephen E. Webber; Kaye J. William; Nicola J. Curtin

doi:10.1093/jnci/djh005

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361

Kaye Williams, Christopher R. Calabrese, Robert Almassy, Stephanie Barton, Michael A. Batey, A. Hilary Calvert, Stacie Canan-Koch, Barbara W. Durkacz, Zdenek Hostomsky, Robert A. Kumpf, Suzanne Kyle, Jianke Li, Karen Maegley, David R. Newell, Elena Notarianni, Ian J. Stratford, Donald Skalitzky, Huw D. Thomas, Lan Zhen Wang, Stephen E. WebberKaye J. William, Nicola J. Curtin

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and radiation therapy in vitro. Because classical PARP-1 inhibitors have limited clinical utility, we investigated whether AG14361, a novel potent PARP-1 inhibitor (inhibition constant

Original language	English
Pages (from-to)	56-67
Number of pages	11
Journal	Journal of the National Cancer Institute
Volume	96
Issue number	1
DOIs	https://doi.org/10.1093/jnci/djh005
Publication status	Published - 7 Jan 2004

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jnci/djh005

Molecular markers and drug development leading to improvements in radiotherapy.
Ian Stratford (Participant), Kaye Williams (Participant), Catharine West (Participant), Caroline Dive (Participant), Rachel Airley (Participant), Amanda Eustace (Participant) & Aoife Shannon (Participant)
Impact: Health impacts

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Williams, K., Calabrese, C. R., Almassy, R., Barton, S., Batey, M. A., Calvert, A. H., Canan-Koch, S., Durkacz, B. W., Hostomsky, Z., Kumpf, R. A., Kyle, S., Li, J., Maegley, K., Newell, D. R., Notarianni, E., Stratford, I. J., Skalitzky, D., Thomas, H. D., Wang, L. Z., ... Curtin, N. J. (2004). Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. Journal of the National Cancer Institute, 96(1), 56-67. https://doi.org/10.1093/jnci/djh005

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title = "Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361",

abstract = "Background: Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and radiation therapy in vitro. Because classical PARP-1 inhibitors have limited clinical utility, we investigated whether AG14361, a novel potent PARP-1 inhibitor (inhibition constant",

author = "Kaye Williams and Calabrese, {Christopher R.} and Robert Almassy and Stephanie Barton and Batey, {Michael A.} and Calvert, {A. Hilary} and Stacie Canan-Koch and Durkacz, {Barbara W.} and Zdenek Hostomsky and Kumpf, {Robert A.} and Suzanne Kyle and Jianke Li and Karen Maegley and Newell, {David R.} and Elena Notarianni and Stratford, {Ian J.} and Donald Skalitzky and Thomas, {Huw D.} and Wang, {Lan Zhen} and Webber, {Stephen E.} and William, {Kaye J.} and Curtin, {Nicola J.}",

year = "2004",

month = jan,

day = "7",

doi = "10.1093/jnci/djh005",

language = "English",

volume = "96",

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journal = "Journal of the National Cancer Institute",

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Williams, K, Calabrese, CR, Almassy, R, Barton, S, Batey, MA, Calvert, AH, Canan-Koch, S, Durkacz, BW, Hostomsky, Z, Kumpf, RA, Kyle, S, Li, J, Maegley, K, Newell, DR, Notarianni, E, Stratford, IJ, Skalitzky, D, Thomas, HD, Wang, LZ, Webber, SE, William, KJ & Curtin, NJ 2004, 'Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361', Journal of the National Cancer Institute, vol. 96, no. 1, pp. 56-67. https://doi.org/10.1093/jnci/djh005

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T1 - Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361

AU - Williams, Kaye

AU - Calabrese, Christopher R.

AU - Almassy, Robert

AU - Barton, Stephanie

AU - Batey, Michael A.

AU - Calvert, A. Hilary

AU - Canan-Koch, Stacie

AU - Durkacz, Barbara W.

AU - Hostomsky, Zdenek

AU - Kumpf, Robert A.

AU - Kyle, Suzanne

AU - Li, Jianke

AU - Maegley, Karen

AU - Newell, David R.

AU - Notarianni, Elena

AU - Stratford, Ian J.

AU - Skalitzky, Donald

AU - Thomas, Huw D.

AU - Wang, Lan Zhen

AU - Webber, Stephen E.

AU - William, Kaye J.

AU - Curtin, Nicola J.

PY - 2004/1/7

Y1 - 2004/1/7

N2 - Background: Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and radiation therapy in vitro. Because classical PARP-1 inhibitors have limited clinical utility, we investigated whether AG14361, a novel potent PARP-1 inhibitor (inhibition constant

AB - Background: Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and radiation therapy in vitro. Because classical PARP-1 inhibitors have limited clinical utility, we investigated whether AG14361, a novel potent PARP-1 inhibitor (inhibition constant

U2 - 10.1093/jnci/djh005

DO - 10.1093/jnci/djh005

M3 - Article

SN - 0027-8874

VL - 96

SP - 56

EP - 67

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 1

ER -

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361

Abstract

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Impacts

Molecular markers and drug development leading to improvements in radiotherapy.

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