Anticardiolipin antibodies in systemic sclerosis: Immunological and clinical associations

R. G. Malia, M. Greaves, L. M. Rowlands, A. C K Lawrence, A. Hume, N. R. Rowell, J. Moult, C. M. Holt, N. Lindsey, P. Hughes

    Research output: Contribution to journalArticlepeer-review


    Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C(1q) binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.
    Original languageEnglish
    Pages (from-to)456-460
    Number of pages4
    JournalClinical and experimental immunology
    Issue number3
    Publication statusPublished - 1988


    • Adult
    • Aged
    • analysis: Autoantibodies
    • immunology: Cardiolipins
    • metabolism: Complement Activating Enzymes
    • metabolism: Complement C1
    • Complement C1q
    • Female
    • Humans
    • analysis: Immunoglobulin G
    • analysis: Immunoglobulin M
    • Male
    • Middle Aged
    • analysis: Platelet Factor 4
    • immunology: Scleroderma, Systemic
    • analysis: beta-Thromboglobulin
    • analysis: von Willebrand Factor


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