Anticardiolipin antibodies in systemic sclerosis: Immunological and clinical associations

R. G. Malia; M. Greaves; L. M. Rowlands; A. C K Lawrence; A. Hume; N. R. Rowell; J. Moult; C. M. Holt; N. Lindsey; P. Hughes

Anticardiolipin antibodies in systemic sclerosis: Immunological and clinical associations

R. G. Malia, M. Greaves, L. M. Rowlands, A. C K Lawrence, A. Hume, N. R. Rowell, J. Moult, C. M. Holt, N. Lindsey, P. Hughes

Research output: Contribution to journal › Article › peer-review

Abstract

Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C(1q) binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.

Original language	English
Pages (from-to)	456-460
Number of pages	4
Journal	Clinical and experimental immunology
Volume	73
Issue number	3
Publication status	Published - 1988

Keywords

Adult
Aged
analysis: Autoantibodies
immunology: Cardiolipins
metabolism: Complement Activating Enzymes
metabolism: Complement C1
Complement C1q
Female
Humans
analysis: Immunoglobulin G
analysis: Immunoglobulin M
Male
Middle Aged
analysis: Platelet Factor 4
immunology: Scleroderma, Systemic
analysis: beta-Thromboglobulin
analysis: von Willebrand Factor

Cite this

@article{55400605bbbd47a0b1168b5fc75e56b7,

title = "Anticardiolipin antibodies in systemic sclerosis: Immunological and clinical associations",

abstract = "Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C(1q) binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.",

keywords = "Adult, Aged, analysis: Autoantibodies, immunology: Cardiolipins, metabolism: Complement Activating Enzymes, metabolism: Complement C1, Complement C1q, Female, Humans, analysis: Immunoglobulin G, analysis: Immunoglobulin M, Male, Middle Aged, analysis: Platelet Factor 4, immunology: Scleroderma, Systemic, analysis: beta-Thromboglobulin, analysis: von Willebrand Factor",

author = "Malia, \{R. G.\} and M. Greaves and Rowlands, \{L. M.\} and Lawrence, \{A. C K\} and A. Hume and Rowell, \{N. R.\} and J. Moult and Holt, \{C. M.\} and N. Lindsey and P. Hughes",

year = "1988",

language = "English",

volume = "73",

pages = "456--460",

journal = "Clinical and experimental immunology",

issn = "0009-9104",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Anticardiolipin antibodies in systemic sclerosis: Immunological and clinical associations

AU - Malia, R. G.

AU - Greaves, M.

AU - Rowlands, L. M.

AU - Lawrence, A. C K

AU - Hume, A.

AU - Rowell, N. R.

AU - Moult, J.

AU - Holt, C. M.

AU - Lindsey, N.

AU - Hughes, P.

PY - 1988

Y1 - 1988

N2 - Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C(1q) binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.

AB - Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C(1q) binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.

KW - Adult

KW - Aged

KW - analysis: Autoantibodies

KW - immunology: Cardiolipins

KW - metabolism: Complement Activating Enzymes

KW - metabolism: Complement C1

KW - Complement C1q

KW - Female

KW - Humans

KW - analysis: Immunoglobulin G

KW - analysis: Immunoglobulin M

KW - Male

KW - Middle Aged

KW - analysis: Platelet Factor 4

KW - immunology: Scleroderma, Systemic

KW - analysis: beta-Thromboglobulin

KW - analysis: von Willebrand Factor

UR - https://www.scopus.com/pages/publications/0023813787

M3 - Article

C2 - 2974767

SN - 0009-9104

VL - 73

SP - 456

EP - 460

JO - Clinical and experimental immunology

JF - Clinical and experimental immunology

IS - 3

ER -

Anticardiolipin antibodies in systemic sclerosis: Immunological and clinical associations

Abstract

Keywords

Other files and links

Fingerprint

Cite this