Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones

Perumal Yogeeswari; Dharmarajan Sriram; Sunil Jit Logantha Ramamoorthy Jeewanlal; Sathiyanesan Sathish Kumar; James P. Stables

doi:10.1016/S0223-5234(02)01338-7

Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones

Perumal Yogeeswari, Dharmarajan Sriram, Sunil Jit Logantha Ramamoorthy Jeewanlal, Sathiyanesan Sathish Kumar, James P. Stables

Research output: Contribution to journal › Article › peer-review

Abstract

Ten 6-chlorobenzothiazolyl-2-thiosemicarbazones were synthesised and screened for anticonvulsant and neurotoxic properties. Most of the compounds showed anticonvulsant activity against both maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole screens. Eight compounds have shown good protection in the rat p.o. MES test at 30 mg kg-1. Compound 1 [4-(6-chlorobenzothiazol-2-yl)-1-(3-isatinimino)thiosemicarbazone] emerged as the most promising one with an ED50 of 17.86 and 6.07 mg kg-1 in mice i.p. and rat p.o., respectively. Compound 1 showed a weak ability to block the expression of fully kindled seizures. © 2002 Published by Éditions scientifiques et médicales Elsevier SAS.

Original language	English
Pages (from-to)	231-236
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/S0223-5234(02)01338-7
Publication status	Published - 1 Mar 2002

Keywords

Benzothiazolylthiosemicarbazones
Electroshock
Fully kindled
Neurotoxicity
Pentylenetetrazole

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10.1016/S0223-5234(02)01338-7

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title = "Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones",

abstract = "Ten 6-chlorobenzothiazolyl-2-thiosemicarbazones were synthesised and screened for anticonvulsant and neurotoxic properties. Most of the compounds showed anticonvulsant activity against both maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole screens. Eight compounds have shown good protection in the rat p.o. MES test at 30 mg kg-1. Compound 1 [4-(6-chlorobenzothiazol-2-yl)-1-(3-isatinimino)thiosemicarbazone] emerged as the most promising one with an ED50 of 17.86 and 6.07 mg kg-1 in mice i.p. and rat p.o., respectively. Compound 1 showed a weak ability to block the expression of fully kindled seizures. {\textcopyright} 2002 Published by {\'E}ditions scientifiques et m{\'e}dicales Elsevier SAS.",

keywords = "Benzothiazolylthiosemicarbazones, Electroshock, Fully kindled, Neurotoxicity, Pentylenetetrazole",

author = "Perumal Yogeeswari and Dharmarajan Sriram and {Logantha Ramamoorthy Jeewanlal}, {Sunil Jit} and Kumar, {Sathiyanesan Sathish} and Stables, {James P.}",

year = "2002",

month = mar,

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doi = "10.1016/S0223-5234(02)01338-7",

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pages = "231--236",

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TY - JOUR

T1 - Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones

AU - Yogeeswari, Perumal

AU - Sriram, Dharmarajan

AU - Logantha Ramamoorthy Jeewanlal, Sunil Jit

AU - Kumar, Sathiyanesan Sathish

AU - Stables, James P.

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Ten 6-chlorobenzothiazolyl-2-thiosemicarbazones were synthesised and screened for anticonvulsant and neurotoxic properties. Most of the compounds showed anticonvulsant activity against both maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole screens. Eight compounds have shown good protection in the rat p.o. MES test at 30 mg kg-1. Compound 1 [4-(6-chlorobenzothiazol-2-yl)-1-(3-isatinimino)thiosemicarbazone] emerged as the most promising one with an ED50 of 17.86 and 6.07 mg kg-1 in mice i.p. and rat p.o., respectively. Compound 1 showed a weak ability to block the expression of fully kindled seizures. © 2002 Published by Éditions scientifiques et médicales Elsevier SAS.

AB - Ten 6-chlorobenzothiazolyl-2-thiosemicarbazones were synthesised and screened for anticonvulsant and neurotoxic properties. Most of the compounds showed anticonvulsant activity against both maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole screens. Eight compounds have shown good protection in the rat p.o. MES test at 30 mg kg-1. Compound 1 [4-(6-chlorobenzothiazol-2-yl)-1-(3-isatinimino)thiosemicarbazone] emerged as the most promising one with an ED50 of 17.86 and 6.07 mg kg-1 in mice i.p. and rat p.o., respectively. Compound 1 showed a weak ability to block the expression of fully kindled seizures. © 2002 Published by Éditions scientifiques et médicales Elsevier SAS.

KW - Benzothiazolylthiosemicarbazones

KW - Electroshock

KW - Fully kindled

KW - Neurotoxicity

KW - Pentylenetetrazole

U2 - 10.1016/S0223-5234(02)01338-7

DO - 10.1016/S0223-5234(02)01338-7

M3 - Article

C2 - 11900867

SN - 0223-5234

VL - 37

SP - 231

EP - 236

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 3

ER -

Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones

Abstract

Keywords

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