Antigen-specific and non-specific depression of proliferative responses induced during contact sensitivity in mice

D. Baker, I. Kimber, K. Ahmed, J. L. Turk

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Exposure of the flank of mice to either oxazolone or trinitrochlorobenzene (TNCB) 5 days prior to the application of oxazolone on the ear resulted in a reduced capacity of oxazolone-induced draining lymph node cells to express IL-2 receptors, produced IL-2, protein, RNA and DNA. However, histological examination of the draining lymph node suggest that antigen-specific and antigen-non-specific influences differ with respect to the frequency of pyroninophilic cells. Pre-exposure to oxazolone suppressed the number of oxazolone-induced pyroninophilic T cell blasts, whereas draining lymph nodes from TNCB-pretreated mice contained significantly more pyroninophilic cells than from oxazolone-pretreated mice. However, the majority of these cells were incorporating little or no thymidine. Thus exposure to certain contact sensitizers induces at least two systemic control mechanisms which serve to regulate subsequent lymphoproliferative responses. These mechanisms appear to exert their influences at different stages of in-vivo T cell activation.
    Original languageEnglish
    Pages (from-to)55-65
    Number of pages10
    JournalInternational Journal of Experimental Pathology
    Volume72
    Issue number1
    Publication statusPublished - 1991

    Keywords

    • Contact sensitivity
    • IL-2 synthesis
    • Proliferation
    • Pyroninophilic cells
    • Suppression

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