Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis

T. I A Roach; D. Wakelin; K. J. Else; D. A P Bundy

Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis

T. I A Roach, D. Wakelin, K. J. Else, D. A P Bundy

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichuria-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval β-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in Elisa, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.

Original language	English
Pages (from-to)	279-291
Number of pages	12
Journal	Parasite Immunology
Volume	10
Issue number	3
Publication status	Published - 1988

Cite this

@article{018996ca6d5649acb5b04b5f2cf84bf7,

title = "Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis",

abstract = "Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichuria-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval β-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in Elisa, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.",

author = "Roach, \{T. I A\} and D. Wakelin and Else, \{K. J.\} and Bundy, \{D. A P\}",

year = "1988",

language = "English",

volume = "10",

pages = "279--291",

journal = "Parasite Immunology",

issn = "1365-3024",

publisher = "John Wiley \& Sons Ltd",

number = "3",

}

TY - JOUR

T1 - Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis

AU - Roach, T. I A

AU - Wakelin, D.

AU - Else, K. J.

AU - Bundy, D. A P

PY - 1988

Y1 - 1988

N2 - Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichuria-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval β-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in Elisa, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.

AB - Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichuria-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval β-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in Elisa, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.

M3 - Article

C2 - 3412784

SN - 1365-3024

VL - 10

SP - 279

EP - 291

JO - Parasite Immunology

JF - Parasite Immunology

IS - 3

ER -

Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis

Abstract

Fingerprint

Cite this