Antimicrobial Macroporous Gel-glasses: Dissolution and Cytotoxicity

P. Saravanapavan, J. E. Gough, J. R. Jones, L. L. Hench

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The incidence of biomaterial-centred infections underlies the need to improve the properties of existing biomaterials. Combining the bioactive properties of calcia-silicate gel-glasses with that of the silver would prevent infections without the use of antibiotic drugs. Inclusion of silver into bioactive gel-glass foam scaffolds is explored using in vitro characterization techniques. The amount of silver released from Ag-doped S70C30 foams is well above the minimum bactericidal concentration (0.1 ppm) but below the cytotoxic concentration (1.6 ppm) for human cells. Primary human osteoblasts proliferate on the silver-doped gel-glasses.
    Original languageEnglish
    Pages (from-to)1087-1090
    Number of pages3
    JournalKey Engineering Materials
    Volume254-256
    DOIs
    Publication statusPublished - 2004

    Keywords

    • Antimicrobial
    • Bioactive glass
    • Macroporous
    • Silver

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