TY - JOUR
T1 - Antimicrobial peptides (AMPs) from fish epidermis: Perspectives for investigative dermatology
AU - Rakers, Sebastian
AU - Niklasson, Lars
AU - Steinhagen, Dieter
AU - Kruse, Charli
AU - Schauber, Jürgen
AU - Sundell, Kristina
AU - Paus, Ralf
PY - 2013/5
Y1 - 2013/5
N2 - Mammalian and fish skin share protective activities against environments that are rich in infectious agents. Fish epidermis is endowed with an extrinsic barrier consisting of a mucus layer and antimicrobial peptides (AMPs). These operate together as a protective chemical shield. As these AMPs are evolutionarily well preserved and also found in higher vertebrate skin (including human epidermis), fish skin offers a unique opportunity to study the origins of innate antimicrobial defense systems. Furthermore, the broad spectrum of fish mucus antimicrobial activities renders piscine AMPs interesting to investigative dermatology, as these may become exploitable for various indications in clinical dermatology. Therefore, this article aims at casting light on fish mucus, the evolutionary relationship between human and fish AMPs, and the latter's antibacterial, antifungal, and even antiviral activities. Moreover, we develop dermatological lessons from, and sketch potential future clinical applications of, fish mucus and piscine AMPs. © 2013 The Society for Investigative Dermatology.
AB - Mammalian and fish skin share protective activities against environments that are rich in infectious agents. Fish epidermis is endowed with an extrinsic barrier consisting of a mucus layer and antimicrobial peptides (AMPs). These operate together as a protective chemical shield. As these AMPs are evolutionarily well preserved and also found in higher vertebrate skin (including human epidermis), fish skin offers a unique opportunity to study the origins of innate antimicrobial defense systems. Furthermore, the broad spectrum of fish mucus antimicrobial activities renders piscine AMPs interesting to investigative dermatology, as these may become exploitable for various indications in clinical dermatology. Therefore, this article aims at casting light on fish mucus, the evolutionary relationship between human and fish AMPs, and the latter's antibacterial, antifungal, and even antiviral activities. Moreover, we develop dermatological lessons from, and sketch potential future clinical applications of, fish mucus and piscine AMPs. © 2013 The Society for Investigative Dermatology.
U2 - 10.1038/jid.2012.503
DO - 10.1038/jid.2012.503
M3 - Article
C2 - 23407389
SN - 1523-1747
VL - 133
SP - 1140
EP - 1149
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -