Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis

Angela E. Gliddon; Caroline J. Doré; Juliet Dunphy; Zoë Betteridge; Neil J. McHugh; Peter J. Maddison; T. Barnes; C. Black; A. Borg; J. Camilleri; K. Chakravarty; C. Denton; P. Emery; B. Griffiths; A. Herrick; N. Hopkinson; P. Hickling; P. Lanyon; C. Laversuch; T. Lawson; R. Mallya; R. Moots; M. Nisar; C. Rhys-Dillon; T. Sheeran

doi:10.3899/jrheum.100754

Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis

Angela E. Gliddon, Caroline J. Doré, Juliet Dunphy, Zoë Betteridge, Neil J. McHugh, Peter J. Maddison, T. Barnes, C. Black, A. Borg, J. Camilleri, K. Chakravarty, C. Denton, P. Emery, B. Griffiths, A. Herrick, N. Hopkinson, P. Hickling, P. Lanyon, C. Laversuch, T. LawsonR. Mallya, R. Moots, M. Nisar, C. Rhys-Dillon, T. Sheeran

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Abstract

Objective. To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc). Methods. Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. Results. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. Conclusion. The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance. The Journal of Rheumatology Copyright © 2011. All rights reserved.

Original language	English
Pages (from-to)	702-705
Number of pages	3
Journal	Journal of Rheumatology
Volume	38
Issue number	4
DOIs	https://doi.org/10.3899/jrheum.100754
Publication status	Published - Apr 2011

Keywords

Autoantibodies
Limited cutaneous systemic sclerosis
Scleroderma

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Gliddon, A. E., Doré, C. J., Dunphy, J., Betteridge, Z., McHugh, N. J., Maddison, P. J., Barnes, T., Black, C., Borg, A., Camilleri, J., Chakravarty, K., Denton, C., Emery, P., Griffiths, B., Herrick, A., Hopkinson, N., Hickling, P., Lanyon, P., Laversuch, C., ... Sheeran, T. (2011). Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis. Journal of Rheumatology, 38(4), 702-705. https://doi.org/10.3899/jrheum.100754

@article{9ce8485d6fe9480185e7f1780bca1e35,

title = "Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis",

abstract = "Objective. To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc). Methods. Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. Results. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. Conclusion. The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance. The Journal of Rheumatology Copyright {\textcopyright} 2011. All rights reserved.",

keywords = "Autoantibodies, Limited cutaneous systemic sclerosis, Scleroderma",

author = "Gliddon, {Angela E.} and Dor{\'e}, {Caroline J.} and Juliet Dunphy and Zo{\"e} Betteridge and McHugh, {Neil J.} and Maddison, {Peter J.} and T. Barnes and C. Black and A. Borg and J. Camilleri and K. Chakravarty and C. Denton and P. Emery and B. Griffiths and A. Herrick and N. Hopkinson and P. Hickling and P. Lanyon and C. Laversuch and T. Lawson and R. Mallya and R. Moots and M. Nisar and C. Rhys-Dillon and T. Sheeran",

year = "2011",

month = apr,

doi = "10.3899/jrheum.100754",

language = "English",

volume = "38",

pages = "702--705",

journal = "Journal of Rheumatology",

issn = "1499-2752",

publisher = "Journal of Rheumatology",

number = "4",

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Gliddon, AE, Doré, CJ, Dunphy, J, Betteridge, Z, McHugh, NJ, Maddison, PJ, Barnes, T, Black, C, Borg, A, Camilleri, J, Chakravarty, K, Denton, C, Emery, P, Griffiths, B, Herrick, A, Hopkinson, N, Hickling, P, Lanyon, P, Laversuch, C, Lawson, T, Mallya, R, Moots, R, Nisar, M, Rhys-Dillon, C & Sheeran, T 2011, 'Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis', Journal of Rheumatology, vol. 38, no. 4, pp. 702-705. https://doi.org/10.3899/jrheum.100754

TY - JOUR

T1 - Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis

AU - Gliddon, Angela E.

AU - Doré, Caroline J.

AU - Dunphy, Juliet

AU - Betteridge, Zoë

AU - McHugh, Neil J.

AU - Maddison, Peter J.

AU - Barnes, T.

AU - Black, C.

AU - Borg, A.

AU - Camilleri, J.

AU - Chakravarty, K.

AU - Denton, C.

AU - Emery, P.

AU - Griffiths, B.

AU - Herrick, A.

AU - Hopkinson, N.

AU - Hickling, P.

AU - Lanyon, P.

AU - Laversuch, C.

AU - Lawson, T.

AU - Mallya, R.

AU - Moots, R.

AU - Nisar, M.

AU - Rhys-Dillon, C.

AU - Sheeran, T.

PY - 2011/4

Y1 - 2011/4

N2 - Objective. To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc). Methods. Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. Results. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. Conclusion. The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance. The Journal of Rheumatology Copyright © 2011. All rights reserved.

AB - Objective. To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc). Methods. Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. Results. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. Conclusion. The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance. The Journal of Rheumatology Copyright © 2011. All rights reserved.

KW - Autoantibodies

KW - Limited cutaneous systemic sclerosis

KW - Scleroderma

U2 - 10.3899/jrheum.100754

DO - 10.3899/jrheum.100754

M3 - Article

C2 - 21239752

SN - 1499-2752

VL - 38

SP - 702

EP - 705

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 4

ER -

Antinuclear antibodies and clinical associations in a British cohort with limited cutaneous systemic sclerosis

Abstract

Keywords

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