Antithymocyte globulin preparations after heart transplantation: Cytokine responses in vivo and in vitro

S. C D Grant; W. R. Lamb; N. Yonan; I. V. Hutchinson; P. E C Brenchley

Antithymocyte globulin preparations after heart transplantation: Cytokine responses in vivo and in vitro

S. C D Grant, W. R. Lamb, N. Yonan, I. V. Hutchinson, P. E C Brenchley

Research output: Contribution to journal › Article › peer-review

Abstract

It is accepted that antithymocyte globulin (ATG) preparations vary in their bioactivity and side effects. However, this is poorly documented in the literature. We compared the clinical course and cytokine response of heart transplant patients who had received either Merieux or Stanford ATG preparations. The serum cytokine response (interleukin [IL]-6, tumor necrosis factor [TNF]-α, IL-4, and IL-10) of 28 consecutive heart transplant recipients was measured for 14 days after surgery using ELISAs. The effect of various ATG preparations on cytokine stimulation of whole blood in vitro was also evaluated. There was a much greater in vivo IL-6 and TNF-α response to Merieux than to Stanford ATG (P

Original language	English
Pages (from-to)	684-689
Number of pages	5
Journal	Transplantation
Volume	60
Issue number	7
Publication status	Published - 1995

Keywords

Adolescent
Adult
therapeutic use: Antilymphocyte Serum
Chemistry, Pharmaceutical
blood: Cytokines
Female
prevention & control: Graft Rejection
immunology: Heart Transplantation
Humans
drug therapy: Infection
Male
Middle Aged

Cite this

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title = "Antithymocyte globulin preparations after heart transplantation: Cytokine responses in vivo and in vitro",

abstract = "It is accepted that antithymocyte globulin (ATG) preparations vary in their bioactivity and side effects. However, this is poorly documented in the literature. We compared the clinical course and cytokine response of heart transplant patients who had received either Merieux or Stanford ATG preparations. The serum cytokine response (interleukin [IL]-6, tumor necrosis factor [TNF]-α, IL-4, and IL-10) of 28 consecutive heart transplant recipients was measured for 14 days after surgery using ELISAs. The effect of various ATG preparations on cytokine stimulation of whole blood in vitro was also evaluated. There was a much greater in vivo IL-6 and TNF-α response to Merieux than to Stanford ATG (P",

keywords = "Adolescent, Adult, therapeutic use: Antilymphocyte Serum, Chemistry, Pharmaceutical, blood: Cytokines, Female, prevention & control: Graft Rejection, immunology: Heart Transplantation, Humans, drug therapy: Infection, Male, Middle Aged",

author = "Grant, {S. C D} and Lamb, {W. R.} and N. Yonan and Hutchinson, {I. V.} and Brenchley, {P. E C}",

year = "1995",

language = "English",

volume = "60",

pages = "684--689",

journal = "Transplantation",

issn = "1534-6080",

publisher = "Lippincott Williams & Wilkins",

number = "7",

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TY - JOUR

T1 - Antithymocyte globulin preparations after heart transplantation: Cytokine responses in vivo and in vitro

AU - Grant, S. C D

AU - Lamb, W. R.

AU - Yonan, N.

AU - Hutchinson, I. V.

AU - Brenchley, P. E C

PY - 1995

Y1 - 1995

N2 - It is accepted that antithymocyte globulin (ATG) preparations vary in their bioactivity and side effects. However, this is poorly documented in the literature. We compared the clinical course and cytokine response of heart transplant patients who had received either Merieux or Stanford ATG preparations. The serum cytokine response (interleukin [IL]-6, tumor necrosis factor [TNF]-α, IL-4, and IL-10) of 28 consecutive heart transplant recipients was measured for 14 days after surgery using ELISAs. The effect of various ATG preparations on cytokine stimulation of whole blood in vitro was also evaluated. There was a much greater in vivo IL-6 and TNF-α response to Merieux than to Stanford ATG (P

AB - It is accepted that antithymocyte globulin (ATG) preparations vary in their bioactivity and side effects. However, this is poorly documented in the literature. We compared the clinical course and cytokine response of heart transplant patients who had received either Merieux or Stanford ATG preparations. The serum cytokine response (interleukin [IL]-6, tumor necrosis factor [TNF]-α, IL-4, and IL-10) of 28 consecutive heart transplant recipients was measured for 14 days after surgery using ELISAs. The effect of various ATG preparations on cytokine stimulation of whole blood in vitro was also evaluated. There was a much greater in vivo IL-6 and TNF-α response to Merieux than to Stanford ATG (P

KW - Adolescent

KW - Adult

KW - therapeutic use: Antilymphocyte Serum

KW - Chemistry, Pharmaceutical

KW - blood: Cytokines

KW - Female

KW - prevention & control: Graft Rejection

KW - immunology: Heart Transplantation

KW - Humans

KW - drug therapy: Infection

KW - Male

KW - Middle Aged

M3 - Article

SN - 1534-6080

VL - 60

SP - 684

EP - 689

JO - Transplantation

JF - Transplantation

IS - 7

ER -

Antithymocyte globulin preparations after heart transplantation: Cytokine responses in vivo and in vitro

Abstract

Keywords

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