Apolipoprotein E-ε4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV

A. N. Jayasuriya, R. F. Itzhaki, M. A. Wozniak, R. Patel, E. J. Smit, R. Noone, G. Gilleran, S. Taylor, D. J. White

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-ε4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-ε4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% Cl 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-ε4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.
    Original languageEnglish
    Pages (from-to)516-517
    Number of pages1
    JournalSexually Transmitted Infections
    Volume84
    Issue number7
    DOIs
    Publication statusPublished - Dec 2008

    Fingerprint

    Dive into the research topics of 'Apolipoprotein E-ε4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV'. Together they form a unique fingerprint.

    Cite this