Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

H Houlden; P Rizzu; M Stevens; P de Knijff; C M van Duijn; J C van Swieten; P Heutink; J Perez-Tur; V Thomas; M Baker; H Morris; M Rossor; J C Jannsen; R C Petersen; P Dodd; F Dark; B Boeve; D Dickson; P Davies; S Pickering-Brown; D Mann; J Adamson; T Lynch; H Payami; J Hardy

Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

H Houlden, P Rizzu, M Stevens, P de Knijff, C M van Duijn, J C van Swieten, P Heutink, J Perez-Tur, V Thomas, M Baker, H Morris, M Rossor, J C Jannsen, R C Petersen, P Dodd, F Dark, B Boeve, D Dickson, P Davies, S Pickering-BrownD Mann, J Adamson, T Lynch, H Payami, J Hardy

Division of Neuroscience

Mayo Clinic

Research output: Contribution to journal › Article › peer-review

Abstract

We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

Original language	English
Pages (from-to)	193-5
Number of pages	3
Journal	Neuroscience letters
Volume	260
Issue number	3
Publication status	Published - 5 Feb 1999

Keywords

Age of Onset
Aged
Apolipoproteins E
Chromosomes, Human, Pair 17
Dementia
Genotype
Humans
Middle Aged
Mutation, Missense
Parkinson Disease
tau Proteins
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Cite this

Houlden, H., Rizzu, P., Stevens, M., de Knijff, P., van Duijn, C. M., van Swieten, J. C., Heutink, P., Perez-Tur, J., Thomas, V., Baker, M., Morris, H., Rossor, M., Jannsen, J. C., Petersen, R. C., Dodd, P., Dark, F., Boeve, B., Dickson, D., Davies, P., ... Hardy, J. (1999). Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neuroscience letters, 260(3), 193-5.

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title = "Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations",

abstract = "We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.",

keywords = "Age of Onset, Aged, Apolipoproteins E, Chromosomes, Human, Pair 17, Dementia, Genotype, Humans, Middle Aged, Mutation, Missense, Parkinson Disease, tau Proteins, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",

author = "H Houlden and P Rizzu and M Stevens and {de Knijff}, P and {van Duijn}, {C M} and {van Swieten}, {J C} and P Heutink and J Perez-Tur and V Thomas and M Baker and H Morris and M Rossor and Jannsen, {J C} and Petersen, {R C} and P Dodd and F Dark and B Boeve and D Dickson and P Davies and S Pickering-Brown and D Mann and J Adamson and T Lynch and H Payami and J Hardy",

year = "1999",

month = feb,

day = "5",

language = "English",

volume = "260",

pages = "193--5",

journal = "Neuroscience letters",

issn = "0304-3940",

publisher = "Elsevier BV",

number = "3",

}

Houlden, H, Rizzu, P, Stevens, M, de Knijff, P, van Duijn, CM, van Swieten, JC, Heutink, P, Perez-Tur, J, Thomas, V, Baker, M, Morris, H, Rossor, M, Jannsen, JC, Petersen, RC, Dodd, P, Dark, F, Boeve, B, Dickson, D, Davies, P, Pickering-Brown, S, Mann, D, Adamson, J, Lynch, T, Payami, H & Hardy, J 1999, 'Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations', Neuroscience letters, vol. 260, no. 3, pp. 193-5.

TY - JOUR

T1 - Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

AU - Houlden, H

AU - Rizzu, P

AU - Stevens, M

AU - de Knijff, P

AU - van Duijn, C M

AU - van Swieten, J C

AU - Heutink, P

AU - Perez-Tur, J

AU - Thomas, V

AU - Baker, M

AU - Morris, H

AU - Rossor, M

AU - Jannsen, J C

AU - Petersen, R C

AU - Dodd, P

AU - Dark, F

AU - Boeve, B

AU - Dickson, D

AU - Davies, P

AU - Pickering-Brown, S

AU - Mann, D

AU - Adamson, J

AU - Lynch, T

AU - Payami, H

AU - Hardy, J

PY - 1999/2/5

Y1 - 1999/2/5

N2 - We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

AB - We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

KW - Age of Onset

KW - Aged

KW - Apolipoproteins E

KW - Chromosomes, Human, Pair 17

KW - Dementia

KW - Genotype

KW - Humans

KW - Middle Aged

KW - Mutation, Missense

KW - Parkinson Disease

KW - tau Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

M3 - Article

C2 - 10076900

SN - 0304-3940

VL - 260

SP - 193

EP - 195

JO - Neuroscience letters

JF - Neuroscience letters

IS - 3

ER -

Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

Abstract

Keywords

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