Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton, Anthony Payton, Eelke H. Van den Boogerd, Fiona Holland, Peter Diggle, Patrick M A Rabbitt, Michael A. Horan, Jane Worthington, William E R Ollier

    Research output: Contribution to journalArticlepeer-review


    There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)74-76
    Number of pages2
    JournalNeuroscience letters
    Issue number1
    Publication statusPublished - 10 May 2002


    • Aged
    • Apolipoprotein E
    • Genetics
    • Intelligence


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