Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton; Anthony Payton; Eelke H. Van den Boogerd; Fiona Holland; Peter Diggle; Patrick M A Rabbitt; Michael A. Horan; Jane Worthington; William E R Ollier

doi:10.1016/S0304-3940(02)00135-0

Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton, Anthony Payton, Eelke H. Van den Boogerd, Fiona Holland, Peter Diggle, Patrick M A Rabbitt, Michael A. Horan, Jane Worthington, William E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	74-76
Number of pages	2
Journal	Neuroscience letters
Volume	324
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00135-0
Publication status	Published - 10 May 2002

Keywords

Aged
Apolipoprotein E
Genetics
Intelligence

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10.1016/S0304-3940(02)00135-0

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title = "Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults",

abstract = "There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults. {\textcopyright} 2002 Elsevier Science Ireland Ltd. All rights reserved.",

keywords = "Aged, Apolipoprotein E, Genetics, Intelligence",

author = "Neil Pendleton and Anthony Payton and {Van den Boogerd}, {Eelke H.} and Fiona Holland and Peter Diggle and Rabbitt, {Patrick M A} and Horan, {Michael A.} and Jane Worthington and Ollier, {William E R}",

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T1 - Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

AU - Pendleton, Neil

AU - Payton, Anthony

AU - Van den Boogerd, Eelke H.

AU - Holland, Fiona

AU - Diggle, Peter

AU - Rabbitt, Patrick M A

AU - Horan, Michael A.

AU - Worthington, Jane

AU - Ollier, William E R

N1 - UI - 21980273DA - 20020501IS - 0304-3940LA - engPT - Journal ArticleRN - 0 (Apolipoproteins E)RN - 0 (apolipoprotein E-2)RN - 0 (apolipoprotein E-4)SB - IM

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N2 - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

AB - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

KW - Aged

KW - Apolipoprotein E

KW - Genetics

KW - Intelligence

U2 - 10.1016/S0304-3940(02)00135-0

DO - 10.1016/S0304-3940(02)00135-0

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SN - 0304-3940

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SP - 74

EP - 76

JO - Neuroscience letters

JF - Neuroscience letters

IS - 1

ER -

Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

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Keywords

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