Apoptosis as a therapeutic target for the treatment of lung disease

Patricia M. de Souza; Mark A. Lindsay

doi:10.1016/j.coph.2005.01.012

Apoptosis as a therapeutic target for the treatment of lung disease

Patricia M. de Souza, Mark A. Lindsay

Research output: Contribution to journal › Article › peer-review

Abstract

It has been speculated that the destruction of lung tissue, associated with several acute and chronic diseases, is in part mediated through apoptosis or programmed cell death. Thus, it has been shown that both increased endothelial/epithelial cell apoptosis and decreased cell death of inflammatory cells are associated with acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. In the light of these observations, it might be possible to use apoptosis modulation as a novel therapeutic approach to the treatment of lung disease. © 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	232-237
Number of pages	5
Journal	Current opinion in pharmacology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/j.coph.2005.01.012
Publication status	Published - Jun 2005

Keywords

Animals
Apoptosis
Caspase 8
physiology: Caspases
physiology: Cell Death
Fas Ligand Protein
Humans
physiology: Membrane Glycoproteins
etiology: Pulmonary Disease, Chronic Obstructive
metabolism: Respiratory Distress Syndrome, Adult
adverse effects: Smoking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coph.2005.01.012

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title = "Apoptosis as a therapeutic target for the treatment of lung disease",

abstract = "It has been speculated that the destruction of lung tissue, associated with several acute and chronic diseases, is in part mediated through apoptosis or programmed cell death. Thus, it has been shown that both increased endothelial/epithelial cell apoptosis and decreased cell death of inflammatory cells are associated with acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. In the light of these observations, it might be possible to use apoptosis modulation as a novel therapeutic approach to the treatment of lung disease. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",

keywords = "Animals, Apoptosis, Caspase 8, physiology: Caspases, physiology: Cell Death, Fas Ligand Protein, Humans, physiology: Membrane Glycoproteins, etiology: Pulmonary Disease, Chronic Obstructive, metabolism: Respiratory Distress Syndrome, Adult, adverse effects: Smoking",

author = "{de Souza}, {Patricia M.} and Lindsay, {Mark A.}",

year = "2005",

month = jun,

doi = "10.1016/j.coph.2005.01.012",

language = "English",

volume = "5",

pages = "232--237",

journal = "Current opinion in pharmacology",

issn = "1471-4892",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Apoptosis as a therapeutic target for the treatment of lung disease

AU - de Souza, Patricia M.

AU - Lindsay, Mark A.

PY - 2005/6

Y1 - 2005/6

N2 - It has been speculated that the destruction of lung tissue, associated with several acute and chronic diseases, is in part mediated through apoptosis or programmed cell death. Thus, it has been shown that both increased endothelial/epithelial cell apoptosis and decreased cell death of inflammatory cells are associated with acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. In the light of these observations, it might be possible to use apoptosis modulation as a novel therapeutic approach to the treatment of lung disease. © 2005 Elsevier Ltd. All rights reserved.

AB - It has been speculated that the destruction of lung tissue, associated with several acute and chronic diseases, is in part mediated through apoptosis or programmed cell death. Thus, it has been shown that both increased endothelial/epithelial cell apoptosis and decreased cell death of inflammatory cells are associated with acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. In the light of these observations, it might be possible to use apoptosis modulation as a novel therapeutic approach to the treatment of lung disease. © 2005 Elsevier Ltd. All rights reserved.

KW - Animals

KW - Apoptosis

KW - Caspase 8

KW - physiology: Caspases

KW - physiology: Cell Death

KW - Fas Ligand Protein

KW - Humans

KW - physiology: Membrane Glycoproteins

KW - etiology: Pulmonary Disease, Chronic Obstructive

KW - metabolism: Respiratory Distress Syndrome, Adult

KW - adverse effects: Smoking

U2 - 10.1016/j.coph.2005.01.012

DO - 10.1016/j.coph.2005.01.012

M3 - Article

SN - 1471-4892

VL - 5

SP - 232

EP - 237

JO - Current opinion in pharmacology

JF - Current opinion in pharmacology

IS - 3

ER -

Apoptosis as a therapeutic target for the treatment of lung disease

Abstract

Keywords

UN SDGs

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