Abstract
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
Original language | English |
---|---|
Pages (from-to) | 1097-1154 |
Number of pages | 58 |
Journal | Cell Death and Differentiation |
Volume | 30 |
Issue number | 5 |
Early online date | 26 Apr 2023 |
DOIs | |
Publication status | Published - May 2023 |
Keywords
- Animals
- Humans
- Apoptosis/genetics
- Cell Death
- Caspases/genetics
- Carcinogenesis
- Mammals/metabolism
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In: Cell Death and Differentiation, Vol. 30, No. 5, 05.2023, p. 1097-1154.
Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - Apoptotic cell death in disease—Current understanding of the NCCD 2023
AU - Vitale, Ilio
AU - Pietrocola, Federico
AU - Guilbaud, Emma
AU - Aaronson, Stuart A.
AU - Abrams, John M.
AU - Adam, Dieter
AU - Agostini, Massimiliano
AU - Agostinis, Patrizia
AU - Alnemri, Emad S.
AU - Altucci, Lucia
AU - Amelio, Ivano
AU - Andrews, David W.
AU - Aqeilan, Rami I.
AU - Arama, Eli
AU - Baehrecke, Eric H.
AU - Balachandran, Siddharth
AU - Bano, Daniele
AU - Barlev, Nickolai A.
AU - Bartek, Jiri
AU - Bazan, Nicolas G.
AU - Becker, Christoph
AU - Bernassola, Francesca
AU - Bertrand, Mathieu J.M.
AU - Bianchi, Marco E.
AU - Blagosklonny, Mikhail V.
AU - Blander, J. Magarian
AU - Blandino, Giovanni
AU - Blomgren, Klas
AU - Borner, Christoph
AU - Bortner, Carl D.
AU - Bove, Pierluigi
AU - Boya, Patricia
AU - Brenner, Catherine
AU - Broz, Petr
AU - Brunner, Thomas
AU - Damgaard, Rune Busk
AU - Calin, George A.
AU - Campanella, Michelangelo
AU - Candi, Eleonora
AU - Carbone, Michele
AU - Carmona-Gutierrez, Didac
AU - Cecconi, Francesco
AU - Chan, Francis K.M.
AU - Chen, Guo Qiang
AU - Chen, Quan
AU - Chen, Youhai H.
AU - Cheng, Emily H.
AU - Chipuk, Jerry E.
AU - Cidlowski, John A.
AU - Ciechanover, Aaron
AU - Ciliberto, Gennaro
AU - Conrad, Marcus
AU - Cubillos-Ruiz, Juan R.
AU - Czabotar, Peter E.
AU - D’Angiolella, Vincenzo
AU - Daugaard, Mads
AU - Dawson, Ted M.
AU - Dawson, Valina L.
AU - De Maria, Ruggero
AU - De Strooper, Bart
AU - Debatin, Klaus Michael
AU - Deberardinis, Ralph J.
AU - Degterev, Alexei
AU - Del Sal, Giannino
AU - Deshmukh, Mohanish
AU - Di Virgilio, Francesco
AU - Diederich, Marc
AU - Dixon, Scott J.
AU - Dynlacht, Brian D.
AU - El-Deiry, Wafik S.
AU - Elrod, John W.
AU - Engeland, Kurt
AU - Fimia, Gian Maria
AU - Galassi, Claudia
AU - Ganini, Carlo
AU - Garcia-Saez, Ana J.
AU - Garg, Abhishek D.
AU - Garrido, Carmen
AU - Gavathiotis, Evripidis
AU - Gerlic, Motti
AU - Ghosh, Sourav
AU - Green, Douglas R.
AU - Greene, Lloyd A.
AU - Gronemeyer, Hinrich
AU - Häcker, Georg
AU - Hajnóczky, György
AU - Hardwick, J. Marie
AU - Haupt, Ygal
AU - He, Sudan
AU - Heery, David M.
AU - Hengartner, Michael O.
AU - Hetz, Claudio
AU - Hildeman, David A.
AU - Ichijo, Hidenori
AU - Inoue, Satoshi
AU - Jäättelä, Marja
AU - Janic, Ana
AU - Joseph, Bertrand
AU - Jost, Philipp J.
AU - Kanneganti, Thirumala Devi
AU - Karin, Michael
AU - Kashkar, Hamid
AU - Kaufmann, Thomas
AU - Kelly, Gemma L.
AU - Kepp, Oliver
AU - Kimchi, Adi
AU - Kitsis, Richard N.
AU - Klionsky, Daniel J.
AU - Kluck, Ruth
AU - Krysko, Dmitri V.
AU - Kulms, Dagmar
AU - Kumar, Sharad
AU - Lavandero, Sergio
AU - Lavrik, Inna N.
AU - Lemasters, John J.
AU - Liccardi, Gianmaria
AU - Linkermann, Andreas
AU - Lipton, Stuart A.
AU - Lockshin, Richard A.
AU - López-Otín, Carlos
AU - Luedde, Tom
AU - MacFarlane, Marion
AU - Madeo, Frank
AU - Malorni, Walter
AU - Manic, Gwenola
AU - Mantovani, Roberto
AU - Marchi, Saverio
AU - Marine, Jean Christophe
AU - Martin, Seamus J.
AU - Martinou, Jean Claude
AU - Mastroberardino, Pier G.
AU - Medema, Jan Paul
AU - Mehlen, Patrick
AU - Meier, Pascal
AU - Melino, Gerry
AU - Melino, Sonia
AU - Miao, Edward A.
AU - Moll, Ute M.
AU - Muñoz-Pinedo, Cristina
AU - Murphy, Daniel J.
AU - Niklison-Chirou, Maria Victoria
AU - Novelli, Flavia
AU - Núñez, Gabriel
AU - Oberst, Andrew
AU - Ofengeim, Dimitry
AU - Opferman, Joseph T.
AU - Oren, Moshe
AU - Pagano, Michele
AU - Panaretakis, Theocharis
AU - Pasparakis, Manolis
AU - Penninger, Josef M.
AU - Pentimalli, Francesca
AU - Pereira, David M.
AU - Pervaiz, Shazib
AU - Peter, Marcus E.
AU - Pinton, Paolo
AU - Porta, Giovanni
AU - Prehn, Jochen H.M.
AU - Puthalakath, Hamsa
AU - Rabinovich, Gabriel A.
AU - Rajalingam, Krishnaraj
AU - Ravichandran, Kodi S.
AU - Rehm, Markus
AU - Ricci, Jean Ehrland
AU - Rizzuto, Rosario
AU - Robinson, Nirmal
AU - Rodrigues, Cecilia M.P.
AU - Rotblat, Barak
AU - Rothlin, Carla V.
AU - Rubinsztein, David C.
AU - Rudel, Thomas
AU - Rufini, Alessandro
AU - Ryan, Kevin M.
AU - Sarosiek, Kristopher A.
AU - Sawa, Akira
AU - Sayan, Emre
AU - Schroder, Kate
AU - Scorrano, Luca
AU - Sesti, Federico
AU - Shao, Feng
AU - Shi, Yufang
AU - Sica, Giuseppe S.
AU - Silke, John
AU - Simon, Hans Uwe
AU - Sistigu, Antonella
AU - Stephanou, Anastasis
AU - Stockwell, Brent R.
AU - Strapazzon, Flavie
AU - Strasser, Andreas
AU - Sun, Liming
AU - Sun, Erwei
AU - Sun, Qiang
AU - Szabadkai, Gyorgy
AU - Tait, Stephen W.G.
AU - Tang, Daolin
AU - Tavernarakis, Nektarios
AU - Troy, Carol M.
AU - Turk, Boris
AU - Urbano, Nicoletta
AU - Vandenabeele, Peter
AU - Vanden Berghe, Tom
AU - Vander Heiden, Matthew G.
AU - Vanderluit, Jacqueline L.
AU - Verkhratsky, Alexei
AU - Villunger, Andreas
AU - von Karstedt, Silvia
AU - Voss, Anne K.
AU - Vousden, Karen H.
AU - Vucic, Domagoj
AU - Vuri, Daniela
AU - Wagner, Erwin F.
AU - Walczak, Henning
AU - Wallach, David
AU - Wang, Ruoning
AU - Wang, Ying
AU - Weber, Achim
AU - Wood, Will
AU - Yamazaki, Takahiro
AU - Yang, Huang Tian
AU - Zakeri, Zahra
AU - Zawacka-Pankau, Joanna E.
AU - Zhang, Lin
AU - Zhang, Haibing
AU - Zhivotovsky, Boris
AU - Zhou, Wenzhao
AU - Piacentini, Mauro
AU - Kroemer, Guido
AU - Galluzzi, Lorenzo
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.
PY - 2023/5
Y1 - 2023/5
N2 - Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
AB - Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
KW - Animals
KW - Humans
KW - Apoptosis/genetics
KW - Cell Death
KW - Caspases/genetics
KW - Carcinogenesis
KW - Mammals/metabolism
UR - http://www.scopus.com/inward/record.url?scp=85153609153&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/57bfaa9a-0a7a-372e-b2ad-dda9def8c12a/
U2 - 10.1038/s41418-023-01153-w
DO - 10.1038/s41418-023-01153-w
M3 - Review article
C2 - 37100955
AN - SCOPUS:85153609153
SN - 1350-9047
VL - 30
SP - 1097
EP - 1154
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
IS - 5
ER -