Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study

Sabrina Doblas, Gilberto S. Almeida, François Xavier Blé, Philippe Garteiser, Benjamin A. Hoff, Dominick J O McIntyre, Lydia Wachsmuth, Thomas L. Chenevert, Cornelius Faber, John R. Griffiths, Andreas H. Jacobs, David M. Morris, James P B O'Connor, Simon P. Robinson, Bernard E. Van Beers, John C. Waterton

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To evaluate between-site agreement of apparent diffusion coefficient (ADC) measurements in preclinical magnetic resonance imaging (MRI) systems. Materials and Methods A miniaturized thermally stable ice-water phantom was devised. ADC (mean and interquartile range) was measured over several days, on 4.7T, 7T, and 9.4T Bruker, Agilent, and Magnex small-animal MRI systems using a common protocol across seven sites. Day-to-day repeatability was expressed as percent variation of mean ADC between acquisitions. Cross-site reproducibility was expressed as 1.96 × standard deviation of percent deviation of ADC values. Results ADC measurements were equivalent across all seven sites with a cross-site ADC reproducibility of 6.3%. Mean day-to-day repeatability of ADC measurements was 2.3%, and no site was identified as presenting different measurements than others (analysis of variance [ANOVA] P = 0.02, post-hoc test n.s.). Between-slice ADC variability was negligible and similar between sites (P = 0.15). Mean within-region-of-interest ADC variability was 5.5%, with one site presenting a significantly greater variation than the others (P = 0.0013). Conclusion Absolute ADC values in preclinical studies are comparable between sites and equipment, provided standardized protocols are employed.

Original languageEnglish
Pages (from-to)1759-1764
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number6
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • apparent diffusion coefficient
  • imaging biomarker
  • preclinical MRI
  • repeatability
  • reproducibility

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