Application of Clinical and Molecular Profiling Data to Improve Patient Outcomes in Psoriatic Arthritis

HIPPOCRATES Consortium, Oliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie- Dumont, Laura Coates, Owen Davies, Maarten De Wit, Filippo Fagni, Carl S Goodyear, Robert Gurke, Lisa Hahnfeld, Christine Huppertz, Vassilios Ioannidis, Mark Ibberson, Arnon Katz, Maximilian Klippstein, Michaela Koehm, Shimon KorishSina Mackay, David Martin, Denis O'Sullivan, Khadijah Patel, Stefan Rueping, Georg Schett, Klaus Scholich, Jochen M. Schwenk, Stefan Siebet, David Simon, Arani Vivekanantham, Stephen R. Pennington

Research output: Contribution to journalArticlepeer-review

Abstract

Achieving a good outcome for a person with Psoriatic Arthritis (PsA) is made difficult by late diagnosis, heterogenous clinical disease expression and in many cases, failure to adequately suppress inflammatory disease features. Single-center studies have certainly contributed to our understanding of disease pathogenesis but to adequately address the major areas of unmet need, multi-partner, collaborative research programmes are now required. HIPPOCRATES is a 5-year, Innovative Medicines Initiative (IMI) programme which includes 17 European academic centers experienced in PsA research, 5 pharmaceutical industry partners, 3 small/medium sized industry partners and 2 patient representative organisations. In this review, the ambitious programme of work to be undertaken by HIPPOCRATES is outlined and common approaches and challenges are identified. It is expected that, when completed, the results will ultimately allow for changes in the approaches to diagnosing, managing, and treating PsA allowing for better short-term and long-term outcomes
Original languageEnglish
JournalTherapeutic Advances in Musculoskeletal Disease
Publication statusAccepted/In press - 26 Jul 2023

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