Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme

Neil G Burnet; Jessica E Scaife; Marina Romanchikova; Simon J Thomas; Amy M Bates; Emma Wong; David J Noble; Leila Ea Shelley; Simon J Bond; Julia R Forman; Andrew Cf Hoole; Gillian C Barnett; Frederic M Brochu; Michael Pd Simmons; Raj Jena; Karl Harrison; Ping Lin Yeap; Amelia Drew; Emma Silvester; Patrick Elwood; Hannah Pullen; Andrew Sultana; Shannon Yk Seah; Megan Z Wilson; Simon G Russell; Richard J Benson; Yvonne L Rimmer; Sarah J Jefferies; Nicolette Taku; Mark Gurnell; Andrew S Powlson; Carola-Bibiane Schönlieb; Xiaohao Cai; Michael Pf Sutcliffe; Michael A Parker

doi:10.23726/cij.2017.457

Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme

Neil G Burnet, Jessica E Scaife, Marina Romanchikova, Simon J Thomas, Amy M Bates, Emma Wong, David J Noble, Leila Ea Shelley, Simon J Bond, Julia R Forman, Andrew Cf Hoole, Gillian C Barnett, Frederic M Brochu, Michael Pd Simmons, Raj Jena, Karl Harrison, Ping Lin Yeap, Amelia Drew, Emma Silvester, Patrick ElwoodHannah Pullen, Andrew Sultana, Shannon Yk Seah, Megan Z Wilson, Simon G Russell, Richard J Benson, Yvonne L Rimmer, Sarah J Jefferies, Nicolette Taku, Mark Gurnell, Andrew S Powlson, Carola-Bibiane Schönlieb, Xiaohao Cai, Michael Pf Sutcliffe, Michael A Parker

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.

Original language	English
Pages (from-to)	3-12
Number of pages	10
Journal	CERN ideaSquare journal of experimental innovation
Volume	1
Issue number	1
DOIs	https://doi.org/10.23726/cij.2017.457
Publication status	Published - 1 Jun 2017

Keywords

Journal Article

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.23726/cij.2017.457Licence: CC BY

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Burnet, N. G., Scaife, J. E., Romanchikova, M., Thomas, S. J., Bates, A. M., Wong, E., Noble, D. J., Shelley, L. E., Bond, S. J., Forman, J. R., Hoole, A. C., Barnett, G. C., Brochu, F. M., Simmons, M. P., Jena, R., Harrison, K., Yeap, P. L., Drew, A., Silvester, E., ... Parker, M. A. (2017). Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme. CERN ideaSquare journal of experimental innovation, 1(1), 3-12. https://doi.org/10.23726/cij.2017.457

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title = "Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme",

abstract = "The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.",

keywords = "Journal Article",

author = "Burnet, {Neil G} and Scaife, {Jessica E} and Marina Romanchikova and Thomas, {Simon J} and Bates, {Amy M} and Emma Wong and Noble, {David J} and Shelley, {Leila Ea} and Bond, {Simon J} and Forman, {Julia R} and Hoole, {Andrew Cf} and Barnett, {Gillian C} and Brochu, {Frederic M} and Simmons, {Michael Pd} and Raj Jena and Karl Harrison and Yeap, {Ping Lin} and Amelia Drew and Emma Silvester and Patrick Elwood and Hannah Pullen and Andrew Sultana and Seah, {Shannon Yk} and Wilson, {Megan Z} and Russell, {Simon G} and Benson, {Richard J} and Rimmer, {Yvonne L} and Jefferies, {Sarah J} and Nicolette Taku and Mark Gurnell and Powlson, {Andrew S} and Carola-Bibiane Sch{\"o}nlieb and Xiaohao Cai and Sutcliffe, {Michael Pf} and Parker, {Michael A}",

year = "2017",

month = jun,

day = "1",

doi = "10.23726/cij.2017.457",

language = "English",

volume = "1",

pages = "3--12",

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Burnet, NG, Scaife, JE, Romanchikova, M, Thomas, SJ, Bates, AM, Wong, E, Noble, DJ, Shelley, LE, Bond, SJ, Forman, JR, Hoole, AC, Barnett, GC, Brochu, FM, Simmons, MP, Jena, R, Harrison, K, Yeap, PL, Drew, A, Silvester, E, Elwood, P, Pullen, H, Sultana, A, Seah, SY, Wilson, MZ, Russell, SG, Benson, RJ, Rimmer, YL, Jefferies, SJ, Taku, N, Gurnell, M, Powlson, AS, Schönlieb, C-B, Cai, X, Sutcliffe, MP & Parker, MA 2017, 'Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme', CERN ideaSquare journal of experimental innovation, vol. 1, no. 1, pp. 3-12. https://doi.org/10.23726/cij.2017.457

Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme. / Burnet, Neil G; Scaife, Jessica E; Romanchikova, Marina et al.
In: CERN ideaSquare journal of experimental innovation, Vol. 1, No. 1, 01.06.2017, p. 3-12.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer

T2 - the multidisciplinary 'VoxTox' research programme

AU - Burnet, Neil G

AU - Scaife, Jessica E

AU - Romanchikova, Marina

AU - Thomas, Simon J

AU - Bates, Amy M

AU - Wong, Emma

AU - Noble, David J

AU - Shelley, Leila Ea

AU - Bond, Simon J

AU - Forman, Julia R

AU - Hoole, Andrew Cf

AU - Barnett, Gillian C

AU - Brochu, Frederic M

AU - Simmons, Michael Pd

AU - Jena, Raj

AU - Harrison, Karl

AU - Yeap, Ping Lin

AU - Drew, Amelia

AU - Silvester, Emma

AU - Elwood, Patrick

AU - Pullen, Hannah

AU - Sultana, Andrew

AU - Seah, Shannon Yk

AU - Wilson, Megan Z

AU - Russell, Simon G

AU - Benson, Richard J

AU - Rimmer, Yvonne L

AU - Jefferies, Sarah J

AU - Taku, Nicolette

AU - Gurnell, Mark

AU - Powlson, Andrew S

AU - Schönlieb, Carola-Bibiane

AU - Cai, Xiaohao

AU - Sutcliffe, Michael Pf

AU - Parker, Michael A

PY - 2017/6/1

Y1 - 2017/6/1

N2 - The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.

AB - The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.

KW - Journal Article

U2 - 10.23726/cij.2017.457

DO - 10.23726/cij.2017.457

M3 - Article

C2 - 29177202

SN - 2413-9505

VL - 1

SP - 3

EP - 12

JO - CERN ideaSquare journal of experimental innovation

JF - CERN ideaSquare journal of experimental innovation

IS - 1

ER -

Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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