Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: Implications for pathophysiology

Pnina Green; Ngozi Anyakoha; Gal Yadid; Iris Gispan-Herman; Anna Nicolaou

doi:10.1016/j.plefa.2009.02.005

Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: Implications for pathophysiology

Pnina Green, Ngozi Anyakoha, Gal Yadid, Iris Gispan-Herman, Anna Nicolaou

Research output: Contribution to journal › Article › peer-review

Abstract

The Flinders Sensitive Line (FSL) rat is a genetic animal model of depression. Following recent findings that the brain fatty acid composition of FSL is characterised by increased arachidonic acid (AA), we used electrospray tandem mass spectrometry and 1H-NMR to examine lipid species in different brain areas. Cholesterol and sphingolipids were increased in the hypothalamus of the FSL rats. Furthermore, arachidonic acid-containing phosphatidylcholine (AA-PC) species were elevated with PC16:0/20:4, PC18:1/20:4 and PC18:0/20:4 (p

Original language	English
Pages (from-to)	213-220
Number of pages	7
Journal	Prostaglandins, Leukotrienes & Essential Fatty Acids
Volume	80
Issue number	4
DOIs	https://doi.org/10.1016/j.plefa.2009.02.005
Publication status	Published - Apr 2009

Keywords

Arachidonic acid
Depression
Electrospray ionisation tandem mass spectrometry
Flinders Sensitive Line rats
High-field NMR
Phosphatidylcholine

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10.1016/j.plefa.2009.02.005

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title = "Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: Implications for pathophysiology",

abstract = "The Flinders Sensitive Line (FSL) rat is a genetic animal model of depression. Following recent findings that the brain fatty acid composition of FSL is characterised by increased arachidonic acid (AA), we used electrospray tandem mass spectrometry and 1H-NMR to examine lipid species in different brain areas. Cholesterol and sphingolipids were increased in the hypothalamus of the FSL rats. Furthermore, arachidonic acid-containing phosphatidylcholine (AA-PC) species were elevated with PC16:0/20:4, PC18:1/20:4 and PC18:0/20:4 (p",

keywords = "Arachidonic acid, Depression, Electrospray ionisation tandem mass spectrometry, Flinders Sensitive Line rats, High-field NMR, Phosphatidylcholine",

author = "Pnina Green and Ngozi Anyakoha and Gal Yadid and Iris Gispan-Herman and Anna Nicolaou",

year = "2009",

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doi = "10.1016/j.plefa.2009.02.005",

language = "English",

volume = "80",

pages = "213--220",

journal = "Prostaglandins, Leukotrienes & Essential Fatty Acids ",

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number = "4",

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Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: Implications for pathophysiology. / Green, Pnina; Anyakoha, Ngozi; Yadid, Gal et al.
In: Prostaglandins, Leukotrienes & Essential Fatty Acids , Vol. 80, No. 4, 04.2009, p. 213-220.

Research output: Contribution to journal › Article › peer-review

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T1 - Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: Implications for pathophysiology

AU - Green, Pnina

AU - Anyakoha, Ngozi

AU - Yadid, Gal

AU - Gispan-Herman, Iris

AU - Nicolaou, Anna

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AB - The Flinders Sensitive Line (FSL) rat is a genetic animal model of depression. Following recent findings that the brain fatty acid composition of FSL is characterised by increased arachidonic acid (AA), we used electrospray tandem mass spectrometry and 1H-NMR to examine lipid species in different brain areas. Cholesterol and sphingolipids were increased in the hypothalamus of the FSL rats. Furthermore, arachidonic acid-containing phosphatidylcholine (AA-PC) species were elevated with PC16:0/20:4, PC18:1/20:4 and PC18:0/20:4 (p

KW - Arachidonic acid

KW - Depression

KW - Electrospray ionisation tandem mass spectrometry

KW - Flinders Sensitive Line rats

KW - High-field NMR

KW - Phosphatidylcholine

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DO - 10.1016/j.plefa.2009.02.005

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VL - 80

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JO - Prostaglandins, Leukotrienes & Essential Fatty Acids

JF - Prostaglandins, Leukotrienes & Essential Fatty Acids

IS - 4

ER -

Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: Implications for pathophysiology

Abstract

Keywords

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