Abstract
(Graph Presented) Light at the end of the tunnel? The rate and kinetic isotope effect of an enzymatic H-tunneling reaction are not dependent on solution viscosity (see picture), despite clear evidence that this reaction is coupled to promoting motions within the protein. This finding is in contrast to the viscosity dependence of conformationally gated electron-transfer reactions and suggests that the mechanisms of environmental gating of these reactions are different. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
| Original language | English |
|---|---|
| Pages (from-to) | 537-540 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2008 |
Keywords
- Enzyme catalysis
- Enzymes
- Quantum chemistry
- Reaction mechanisms