Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?

Sam Hay, Christopher R. Pudney, Michael J. Sutcliffe, Nigel S. Scrutton

    Research output: Contribution to journalArticlepeer-review

    Abstract

    (Graph Presented) Light at the end of the tunnel? The rate and kinetic isotope effect of an enzymatic H-tunneling reaction are not dependent on solution viscosity (see picture), despite clear evidence that this reaction is coupled to promoting motions within the protein. This finding is in contrast to the viscosity dependence of conformationally gated electron-transfer reactions and suggests that the mechanisms of environmental gating of these reactions are different. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)537-540
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Volume47
    Issue number3
    DOIs
    Publication statusPublished - 2008

    Keywords

    • Enzyme catalysis
    • Enzymes
    • Quantum chemistry
    • Reaction mechanisms

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