Abstract
Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling proteins such as ryanodine receptor (RyR), L-type calcium current and sodium/calcium exchanger. In this article, we review all the data available on the effects of omega-3 fatty acids on ventricular myocardial calcium handling. In addition we highlight some unanswered questions and discuss possible therapeutic benefits of omega-3 fatty acids. © 2012 Sankaranarayanan and Venetucci.
| Original language | English |
|---|---|
| Article number | Article 373 |
| Journal | Frontiers in Physiology |
| Volume | 3 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- Anti-arrhythmics
- Calcium
- Fatty acids
- Fish oils
- Omega-3