Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

Claire L. Arthurs; James Raftery; Helen L. Whitby; Roger C. Whitehead; Natasha S. Wind; Ian J. Stratford

doi:10.1016/j.bmcl.2007.07.070

Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

Claire L. Arthurs, James Raftery, Helen L. Whitby, Roger C. Whitehead, Natasha S. Wind, Ian J. Stratford

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented. © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	5974-5977
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2007.07.070
Publication status	Published - 1 Nov 2007

Keywords

Anti-tumour
COTC
Glutathione
Glutathione transferase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2007.07.070

CCDC 630924: Experimental Crystal Structure Determination
Arthurs, C. L. (Contributor), Raftery, J. (Contributor), Whitby, H. L. (Contributor), Whitehead, R. (Contributor), Wind, N. S. (Contributor) & Stratford, I. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2008
DOI: 10.5517/ccp5jdr, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccp5jdr&sid=DataCite
Dataset

Cite this

Arthurs, C. L., Raftery, J., Whitby, H. L., Whitehead, R. C., Wind, N. S., & Stratford, I. J. (2007). Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC). Bioorganic and Medicinal Chemistry Letters, 17(21), 5974-5977. https://doi.org/10.1016/j.bmcl.2007.07.070

@article{c0cc54294db042c1a3f3bc01e2a71b40,

title = "Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)",

abstract = "The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

keywords = "Anti-tumour, COTC, Glutathione, Glutathione transferase",

author = "Arthurs, {Claire L.} and James Raftery and Whitby, {Helen L.} and Whitehead, {Roger C.} and Wind, {Natasha S.} and Stratford, {Ian J.}",

note = "Arthurs, Claire L. Raftery, James Whitby, Helen L. Whitehead, Roger C. Wind, Natasha S. Stratford, Ian J. 27 PERGAMON-ELSEVIER SCIENCE LTD OXFORD 222HU",

year = "2007",

month = nov,

day = "1",

doi = "10.1016/j.bmcl.2007.07.070",

language = "English",

volume = "17",

pages = "5974--5977",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "1464-3405",

publisher = "Elsevier BV",

number = "21",

}

Arthurs, CL, Raftery, J, Whitby, HL, Whitehead, RC, Wind, NS & Stratford, IJ 2007, 'Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 21, pp. 5974-5977. https://doi.org/10.1016/j.bmcl.2007.07.070

Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC). / Arthurs, Claire L.; Raftery, James; Whitby, Helen L. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 21, 01.11.2007, p. 5974-5977.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

AU - Arthurs, Claire L.

AU - Raftery, James

AU - Whitby, Helen L.

AU - Whitehead, Roger C.

AU - Wind, Natasha S.

AU - Stratford, Ian J.

N1 - Arthurs, Claire L. Raftery, James Whitby, Helen L. Whitehead, Roger C. Wind, Natasha S. Stratford, Ian J. 27 PERGAMON-ELSEVIER SCIENCE LTD OXFORD 222HU

PY - 2007/11/1

Y1 - 2007/11/1

N2 - The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented. © 2007 Elsevier Ltd. All rights reserved.

AB - The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented. © 2007 Elsevier Ltd. All rights reserved.

KW - Anti-tumour

KW - COTC

KW - Glutathione

KW - Glutathione transferase

U2 - 10.1016/j.bmcl.2007.07.070

DO - 10.1016/j.bmcl.2007.07.070

M3 - Article

SN - 1464-3405

VL - 17

SP - 5974

EP - 5977

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 21

ER -

Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

Abstract

Keywords

UN SDGs

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Datasets

CCDC 630924: Experimental Crystal Structure Determination

Cite this