Aromatic stacking - the key step in the nucleation of aromatic benzoic acids

Aurora Cruz Cabeza, Roger Davey, Sharlinda Salim Sachithananthan, Rebecca Smith, Sin Kim Tang, Thomas Vetter, Xiao Yang

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    Crystal nucleation from solution is of central importance in the chemical and biological sciences. Linking nucleation kinetics to the properties of solutes and solvents remains a grand-challenge in physical chemistry. Through a unique dataset of compounds able to self-assemble via both hydrogen-bonds and aromatic stacks, we are able to compare the importance of these two types of interaction in driving the nucleation process. Contrary to previous reports in which solution chemistry and hydrogen bonding have been seen as controlling factors, we are now able to show that cluster growth via aromatic stacking holds the key.
    Original languageEnglish
    Pages (from-to)7905-7908
    JournalChemical Communications
    Issue number56
    Early online date22 Jun 2017
    Publication statusPublished - 22 Jun 2017


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