Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules

Mai Elhemely; Asma Belgath; Sherihan El Sayed; Kepa Burusco-Goni; Manikandan Kadirvel; Annalisa Tirella; Katie Finegan; Richard Bryce; Ian Stratford; Sally Freeman

doi:10.1021/acs.jmedchem.1c01936.

Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules

Mai Elhemely, Asma Belgath, Sherihan El Sayed, Kepa Burusco-Goni, Manikandan Kadirvel, Annalisa Tirella, Katie Finegan, Richard Bryce, Ian Stratford, Sally Freeman

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4783-4797
Journal	Journal of Medicinal Chemistry
Volume	65
Issue number	6
DOIs	https://doi.org/10.1021/acs.jmedchem.1c01936.
Publication status	Published - 15 Mar 2022

Access to Document

10.1021/acs.jmedchem.1c01936.

Cite this

Elhemely, M., Belgath, A., El Sayed, S., Burusco-Goni, K., Kadirvel, M., Tirella, A., Finegan, K., Bryce, R., Stratford, I., & Freeman, S. (2022). Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules. Journal of Medicinal Chemistry, 65(6), 4783-4797. https://doi.org/10.1021/acs.jmedchem.1c01936.

@article{829a84f1472c48f5be331a6e638997dd,

title = "Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules",

author = "Mai Elhemely and Asma Belgath and {El Sayed}, Sherihan and Kepa Burusco-Goni and Manikandan Kadirvel and Annalisa Tirella and Katie Finegan and Richard Bryce and Ian Stratford and Sally Freeman",

year = "2022",

month = mar,

day = "15",

doi = "10.1021/acs.jmedchem.1c01936.",

language = "English",

volume = "65",

pages = "4783--4797",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "6",

}

Elhemely, M, Belgath, A, El Sayed, S , Burusco-Goni, K, Kadirvel, M, Tirella, A , Finegan, K , Bryce, R , Stratford, I & Freeman, S 2022, 'Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules', Journal of Medicinal Chemistry, vol. 65, no. 6, pp. 4783-4797. https://doi.org/10.1021/acs.jmedchem.1c01936.

TY - JOUR

T1 - Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules

AU - Elhemely, Mai

AU - Belgath, Asma

AU - El Sayed, Sherihan

AU - Burusco-Goni, Kepa

AU - Kadirvel, Manikandan

AU - Tirella, Annalisa

AU - Finegan, Katie

AU - Bryce, Richard

AU - Stratford, Ian

AU - Freeman, Sally

PY - 2022/3/15

Y1 - 2022/3/15

U2 - 10.1021/acs.jmedchem.1c01936.

DO - 10.1021/acs.jmedchem.1c01936.

M3 - Article

VL - 65

SP - 4783

EP - 4797

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 6

ER -