Aspergillus nodules in chronic granulomatous disease attributable to Aspergillus ochraceus

Samihah Moazam; David W. Denning

doi:10.1016/j.mmcr.2017.06.004

Aspergillus nodules in chronic granulomatous disease attributable to Aspergillus ochraceus

Samihah Moazam, David W. Denning^*

^*Corresponding author for this work

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Aspergillus ochraceus is a rare pulmonary pathogen. A 39 year old male with COPD and chronic granulomatous disease presented with severe breathlessness and recurrent infections. CT scan demonstrated multiple pulmonary nodules diagnosed as chronic pulmonary aspergillosis. The patient's sputum grew Aspergillus ochraceus thrice over 6 months, alongside positive Aspergillus IgG and serum galactomannan. Despite treatment with itraconazole, the patient continued to be symptomatic. We present the first case associating A. ochraceus with chronic pulmonary aspergillosis.

Original language	English
Pages (from-to)	31-33
Number of pages	3
Journal	Medical Mycology Case Reports
Volume	17
Early online date	21 Jun 2017
DOIs	https://doi.org/10.1016/j.mmcr.2017.06.004
Publication status	Published - 2017

Keywords

Amphotericin B
Aspergillus
niger
Ochratoxin A
Resistance

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10.1016/j.mmcr.2017.06.004

Moazam Nodule ochraceus Med Myco case Rep 2017Final published version, 663 KBLicence: CC BY-NC-ND

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title = "Aspergillus nodules in chronic granulomatous disease attributable to Aspergillus ochraceus",

abstract = "Aspergillus ochraceus is a rare pulmonary pathogen. A 39 year old male with COPD and chronic granulomatous disease presented with severe breathlessness and recurrent infections. CT scan demonstrated multiple pulmonary nodules diagnosed as chronic pulmonary aspergillosis. The patient's sputum grew Aspergillus ochraceus thrice over 6 months, alongside positive Aspergillus IgG and serum galactomannan. Despite treatment with itraconazole, the patient continued to be symptomatic. We present the first case associating A. ochraceus with chronic pulmonary aspergillosis.",

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AB - Aspergillus ochraceus is a rare pulmonary pathogen. A 39 year old male with COPD and chronic granulomatous disease presented with severe breathlessness and recurrent infections. CT scan demonstrated multiple pulmonary nodules diagnosed as chronic pulmonary aspergillosis. The patient's sputum grew Aspergillus ochraceus thrice over 6 months, alongside positive Aspergillus IgG and serum galactomannan. Despite treatment with itraconazole, the patient continued to be symptomatic. We present the first case associating A. ochraceus with chronic pulmonary aspergillosis.

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KW - Aspergillus

KW - niger

KW - Ochratoxin A

KW - Resistance

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JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

ER -

Aspergillus nodules in chronic granulomatous disease attributable to Aspergillus ochraceus

Abstract

Keywords

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